Transcription Factor
| Accessions: | MITF_MOUSE (HOCOMOCO 10), Q08874 (JASPAR 2024) |
| Names: | MITF_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q08874 |
| Length: | 526 |
| Pfam Domains: | 312-365 Helix-loop-helix DNA-binding domain 397-522 Domain of unknown function (DUF3371) |
| Sequence: (in bold interface residues) | 1 MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHSGASKPPLSSSTMTSRILLR 60 61 QQLMREQMQEQERREQQQKLQAAQFMQQRVAVSQTPAINVSVPTTLPSATQVPMEVLKVQ 120 121 THLENPTKYHIQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDHAMPPVPGSSAPNS 180 181 PMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEE 240 241 ILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTACIFPTE 300 301 SEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDY 360 361 IRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPSTGLCSPDLVNR 420 421 IIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTITFTNNLGTMPESSPAYSIPRKMGSN 480 481 LEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC |
| Interface Residues: | 313, 315, 316, 317, 319, 320, 323, 324, 348, 350 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 4zpk_A, 7ssa_L, 6g1l_A, 5eyo_A, 7xi3_A, 5nj8_D, 4h10_A, 7d8t_A, 5gnj_I, 1am9_A, 8osl_O, 5v0l_A, 4h10_B, 7f2f_B, 5i50_B, 8osl_P, 2ypa_A, 5nj8_C, 5v0l_B |
| Binding Motifs: | MA0620.1 rrTCACGtGg MITF_MOUSE.H10MO.C|M01210 rtCAtGTGmb |
| Publications: | McGill G. G., Horstmann M., Widlund H. R., Du J., Motyckova G., Nishimura E. K., Lin Y. L., Ramaswamy S., Avery W., Ding H. F., Jordan S. A., Jackson I. J., Korsmeyer S. J., Golub T. R., Fisher D. E. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.. Cell 109:707-718 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.