Transcription Factor

Accessions: Q15562 (JASPAR 2024)
Names: TEA domain family member 2, TEAD-2, TEAD2_HUMAN, Transcriptional enhancer factor TEF-4
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q15562
Length: 447
Pfam Domains: 20-439 TEA/ATTS domain family
Sequence:
(in bold interface residues)
1 MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIY 60
61 PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLK 120
121 DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPF 180
181 SQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPP 240
241 DAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLV 300
301 KFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVET 360
361 ERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQEL 420
421 LLCTAYVFEVSTSERGAQHHIYRLVRD
Interface Residues: 76, 80, 97, 98, 101, 102, 105, 106, 109
3D-footprint Homologues: 5gzb_A, 5no6_N
Binding Motifs: MA1121.1 hcACATTCCwgsc
MA1121.2 ACATTCC
Binding Sites: MA1121.1.1
MA1121.1.10
MA1121.1.11
MA1121.1.12
MA1121.1.13
MA1121.1.14
MA1121.1.15
MA1121.1.16
MA1121.1.17
MA1121.1.18
MA1121.1.19
MA1121.1.2
MA1121.1.20
MA1121.1.3
MA1121.1.4
MA1121.1.5
MA1121.1.6
MA1121.1.7
MA1121.1.8
MA1121.1.9
MA1121.2.18
MA1121.2.1
MA1121.2.10 / MA1121.2.11 / MA1121.2.12 / MA1121.2.14 / MA1121.2.15 / MA1121.2.17 / MA1121.2.20 / MA1121.2.4 / MA1121.2.5
MA1121.2.13 / MA1121.2.2 / MA1121.2.6 / MA1121.2.8
MA1121.2.16
MA1121.2.19
MA1121.2.3
MA1121.2.7
MA1121.2.9
Publications: Wasserman W.W, Fickett J.W. Identification of regulatory regions which confer muscle-specific gene expression. Journal of molecular biology 278:167-81 (1998). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.