Transcription Factor

Accessions: JDP2_DBD (HumanTF 1.0), JDP2 (HT-SELEX2 May2017)
Names: JDP2, JDP2_HUMAN, ENSG00000140044
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: Q8WYK2
Notes: Ensembl ID: ENSG00000140044; DNA-binding domain sequence; TF family: bZIP; Clone source: Megaman, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 101
Pfam Domains: 20-78 bZIP transcription factor
21-74 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 HFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELM 60
61 NAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPES
Interface Residues: 28, 29, 32, 33, 35, 36, 39, 40
3D-footprint Homologues: 2wt7_A, 2wt7_B, 3a5t_B, 4eot_A, 1nwq_C, 2e42_A, 5t01_B, 1t2k_D, 1dh3_C
Binding Motifs: JDP2_DBD_1 ATGAsTCAT
JDP2_DBD_2 gATGACGTCAyc
JDP2_3 srTGACGTCAys
JDP2_4 sATGAsTCATs
JDP2_7 srTgAyGTmAys
JDP2_8 srTGmskCAys
JDP2_methyl_1 grTGAyGTCAyc
JDP2_methyl_2 gATGAsTCAyc
JDP2_methyl_5 srTGAyGTcAys
JDP2_methyl_6 srTGAsTCAys
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

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