Transcription Factor

Accessions: T144608_1.02 (CISBP 1.02), P43267 (JASPAR 2024)
Names: Sox15, T144608_1.02;, SOX15_MOUSE
Organisms: Mus musculus
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P43267
Notes: experiment type:PBM, family:Sox
Length: 231
Pfam Domains: 46-108 Domain of unknown function (DUF1898)
47-115 HMG (high mobility group) box
Sequence:
(in bold interface residues)
1 MALTSSSQAETWSLHPRASTASLPLGPQEQEAGGSPGASGGLPLEKVKRPMNAFMVWSSV 60
61 QRRQMAQQNPKMHNSEISKRLGAQWKLLGDEEKRPFVEEAKRLRARHLRDYPDYKYRPRR 120
121 KSKNSSTGSVPFSQEGGGLACGGSHWGPGYTTTQGSRGFGYQPPNYSTAYLPGSYTSSHC 180
181 RPEAPLPCTFPQSDPRLQGELRPSFSPYLSPDSSTPYNTSLAGAPMPVTHL
Interface Residues: 49, 52, 54, 55, 56, 58, 62, 73, 74, 75, 78, 116, 120
3D-footprint Homologues: 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 1hry_A, 3tq6_B, 1ckt_A
Binding Motifs: PB0065.1 wrkwgAACAATwrrtwt
PB0169.1 btramTGwmATtysr
M1590_1.02 aTTswtyww
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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