Transcription Factor

						

			
Accessions: HNF1A_HUMAN (HOCOMOCO 10), ABR09270 (JASPAR 2024), P20823 (JASPAR 2024)

			
Names: Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, HNF1A_HUMAN, LFB1, Liver-specific transcription factor LF-B1, TCF-1, Transcription factor 1
Organisms: Homo sapiens, Vertebrata
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 631
Pfam Domains:     1-176 Hepatocyte nuclear factor 1 (HNF-1), N terminus
  200-273 Homeobox domain
  282-541 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
  542-630 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
Sequence: 
(in bold interface residues)		   1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAEL   60
  61 PNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVK  120
 121 SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA  180
 181 GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE  240
 241 CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP  300
 301 AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH  360
 361 SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA  420
 421 SLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPV  480
 481 QSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK  540
 541 QVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQS  600
 601 SDSSNGQSHLLPSNHSVIETFISTQMASSSQ
Interface Residues: 140, 141, 142, 143, 145, 146, 152, 153, 200, 201, 203, 263, 264, 265, 266, 269, 270, 273
3D-footprint Homologues: 2h8r_B, 1ic8_B, 1fjl_B, 5zfz_A, 3cmy_A, 2lkx_A, 4j19_B, 1puf_B, 1le8_A
Binding Motifs: MA0046.1 gGTTAATwwTTamc
MA0046.2 arTTAATsATTAACw
HNF1A_HUMAN.H10MO.A|M01223 rGTTAATawTTamcm
MA0046.3 rTTAATsATTAAC
Binding Sites: MA0046.1.1
MA0046.1.10
MA0046.1.11
MA0046.1.12
MA0046.1.13
MA0046.1.14
MA0046.1.15
MA0046.1.16
MA0046.1.17
MA0046.1.18
MA0046.1.19
MA0046.1.2
MA0046.1.20
MA0046.1.3
MA0046.1.4
MA0046.1.5
MA0046.1.6
MA0046.1.7
MA0046.1.8
MA0046.1.9
			
Publications: Tronche F, Ringeisen F, Blumenfeld M, Yaniv M, Pontoglio M. Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome. Journal of molecular biology 266:231-45 (1997). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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