Transcription Factor
| Accessions: | bcd (DrosophilaTF 1.1), P09081 (JASPAR 2024) |
| Names: | BCD_DROME, Homeotic protein bicoid, PRD-4 |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P09081 |
| Length: | 494 |
| Pfam Domains: | 98-153 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAQPPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDER 60 61 TGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGR 120 121 YLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDP 180 181 PSLQTLSLGGGATPNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQ 240 241 YPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQYHHFDF 300 301 QQKQASACRVLVKDEPEADYNFNSSYYMRSGMSGATASASAVARGAASPGSEVYEPLTPK 360 361 NDESPSLCGIGIGGPCAIAVGETEAADDMDDGTSKKTTLQILEPLKGLDKSCDDGSSDDM 420 421 STGIRALAGTGNRGAAFAKFGKPSPPQGPQPPLGMGGVAMGESNQYQCTMDTIMQAYNPH 480 481 RNAAGNSQFAYCFN |
| Interface Residues: | 65, 98, 99, 100, 101, 139, 140, 142, 143, 146, 147, 150, 151, 154, 157 |
| 3D-footprint Homologues: | 3l1p_A, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 1ig7_A, 3cmy_A, 5zfz_A, 6fqp_B, 3d1n_M, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 6es3_K, 7q3o_C, 1au7_A, 5hod_A, 3a01_E, 7psx_B, 1b72_A, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1k61_B, 1o4x_A, 8g87_X, 4qtr_D, 1mnm_C, 1du0_A |
| Binding Motifs: | MA0212.1 TAATCC bcd ssvcTAATCCb |
| Binding Sites: | bcd_S26-17a bcd_S26-17b bcd_S28-1 bcd_S28-1" bcd_S28-1' bcd_S28-10 bcd_S28-10' bcd_S28-11' bcd_S28-11a bcd_S28-11b bcd_S28-12a bcd_S28-12b bcd_S28-13 bcd_S28-14' bcd_S28-14a bcd_S28-14b bcd_S28-15a bcd_S28-15b bcd_S28-16 bcd_S28-16' bcd_S28-18' bcd_S28-19 bcd_S28-2 bcd_S28-20a bcd_S28-20b bcd_S28-3 bcd_S28-4 bcd_S28-4' bcd_S28-5' bcd_S28-5a bcd_S28-5b bcd_S28-6 bcd_S28-7 bcd_S28-7' bcd_S28-9 MA0212.1.17 MA0212.1.1 MA0212.1.10 MA0212.1.11 MA0212.1.12 MA0212.1.13 MA0212.1.14 MA0212.1.15 MA0212.1.16 MA0212.1.18 MA0212.1.19 MA0212.1.2 MA0212.1.20 MA0212.1.3 MA0212.1.4 MA0212.1.5 MA0212.1.6 MA0212.1.7 MA0212.1.8 MA0212.1.9 |
| Publications: | Wilson D.S, Sheng G, Jun S, Desplan C. Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proceedings of the National Academy of Sciences of the United States of America 93:6886-91 (1996). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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