Transcription Factor
| Accessions: | PPARG_HUMAN (HOCOMOCO 10), P37231 (JASPAR 2024) |
| Names: | Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 505 |
| Pfam Domains: | 31-108 PPAR gamma N-terminal region 138-204 Zinc finger, C4 type (two domains) 321-484 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF 60 61 DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT 120 121 QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC 180 181 RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR 240 241 ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE 300 301 QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS 360 361 LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII 420 421 LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL 480 481 LQVIKKTETDMSLHPLLQEIYKDLY |
| Interface Residues: | 147, 148, 150, 151, 157, 158, 160, 161, 164, 165, 188, 210, 212, 214, 218, 220 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B |
| Binding Motifs: | PPARG_HUMAN.H10MO.A|M01459 awstrGGkcAAAGGkcA MA0065.1 yywrrGGTCAAAGGTCAymk MA0066.1 sTrGGTCAcsgTGACCyAcW MA0066.2 TrGGTCAcsgTGACCyAcW |
| Binding Sites: | MA0065.1.12 MA0065.1.14 MA0065.1.6 MA0065.1.1 MA0065.1.10 MA0065.1.11 MA0065.1.13 MA0065.1.15 MA0065.1.16 MA0065.1.17 MA0065.1.18 MA0065.1.19 MA0065.1.2 MA0065.1.20 MA0065.1.3 MA0065.1.4 MA0065.1.5 MA0065.1.7 MA0065.1.8 MA0065.1.9 MA0066.1.1 MA0066.1.10 MA0066.1.11 MA0066.1.12 MA0066.1.13 MA0066.1.14 MA0066.1.15 MA0066.1.16 MA0066.1.17 MA0066.1.18 MA0066.1.19 MA0066.1.2 MA0066.1.20 MA0066.1.3 MA0066.1.4 / MA0066.1.5 MA0066.1.6 MA0066.1.7 MA0066.1.8 MA0066.1.9 MA0066.2.1 / MA0066.2.10 MA0066.2.11 MA0066.2.12 MA0066.2.13 MA0066.2.14 MA0066.2.15 MA0066.2.16 MA0066.2.17 MA0066.2.18 MA0066.2.19 MA0066.2.2 MA0066.2.20 MA0066.2.3 MA0066.2.4 / MA0066.2.5 MA0066.2.6 MA0066.2.7 MA0066.2.8 MA0066.2.9 |
| Publications: | Okuno M., Arimoto E., Ikenobu Y., Nishihara T., Imagawa M. Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha. Biochem. J. 353:193-198 (2001). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.