Transcription Factor

Accessions: NFKB1_HUMAN (HOCOMOCO 10), P19838 (JASPAR 2024)
Names: DNA-binding factor KBF1, EBP-1, NFKB1_HUMAN, Nuclear factor NF-kappa-B p105 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Organisms: Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P19838
Length: 968
Pfam Domains: 44-242 Rel homology domain (RHD)
547-639 Ankyrin repeats (3 copies)
583-612 Ankyrin repeat
583-609 Ankyrin repeat
615-637 Ankyrin repeat
619-710 Ankyrin repeats (3 copies)
650-680 Ankyrin repeat
652-705 Ankyrin repeats (many copies)
718-749 Ankyrin repeat
818-891 Death domain
Sequence:
(in bold interface residues)
1 MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV 60
61 CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED 120
121 GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA 180
181 EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY 240
241 DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF 300
301 SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ 360
361 RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH 420
421 PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE 480
481 VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD 540
541 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 600
601 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM 660
661 SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT 720
721 TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT 780
781 SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG 840
841 LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ 900
901 AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ 960
961 EGPLEGKI
Interface Residues: 56, 58, 59, 61, 62, 64, 65, 66, 243, 245, 274, 307
3D-footprint Homologues: 2ram_A, 1gji_A, 7cli_B, 1nfk_A, 2o61_A, 1a3q_A
Binding Motifs: MA0105.4 AGGGGAwTCCCCt
MA0105.3 kGGraTTYCCm
NFKB1_HUMAN.H10MO.B|M01366 gGGrAAkyCCC
MA0105.1 GGGrmTTyCC
MA0105.2 GGGGrwyYCCC
Binding Sites: MA0105.1.12
MA0105.1.10 / MA0105.1.4 / MA0105.1.5 / MA0105.1.6 / MA0105.1.7 / MA0105.1.8 / MA0105.1.9
MA0105.1.13 / MA0105.1.14 / MA0105.1.15
MA0105.1.17
MA0105.1.1 / MA0105.1.2 / MA0105.1.3
MA0105.1.16
MA0105.1.20
MA0105.1.19
MA0105.1.11
MA0105.1.18
MA0105.2.1
MA0105.2.10
MA0105.2.11
MA0105.2.12
MA0105.2.13
MA0105.2.14
MA0105.2.15
MA0105.2.16
MA0105.2.17
MA0105.2.18
MA0105.2.2
MA0105.2.3
MA0105.2.4
MA0105.2.5
MA0105.2.6
MA0105.2.7
MA0105.2.8
MA0105.2.9
MA0105.3.1
MA0105.3.10
MA0105.3.11
MA0105.3.12 / MA0105.3.13
MA0105.3.14
MA0105.3.15
MA0105.3.16
MA0105.3.17
MA0105.3.18
MA0105.3.19
MA0105.3.2
MA0105.3.20
MA0105.3.3
MA0105.3.4
MA0105.3.5
MA0105.3.6
MA0105.3.7
MA0105.3.8
MA0105.3.9
Publications: Kunsch C., Ruben S. M., Rosen C. A. Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412-4421 (1992). [Pubmed]

Grilli M., Chiu J. J.-S., Lenardo M. J. NF-kappaB and Rel: Participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1-62 (1993). [Pubmed]

Wan F, Lenardo MJ. Specification of DNA binding activity of NF-kappaB proteins. Cold Spring Harb Perspect Biol : (2009). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.