Transcription Factor
Accessions: | NFKB1_HUMAN (HOCOMOCO 10), P19838 (JASPAR 2024) |
Names: | DNA-binding factor KBF1, EBP-1, NFKB1_HUMAN, Nuclear factor NF-kappa-B p105 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Organisms: | Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P19838 |
Length: | 968 |
Pfam Domains: | 44-242 Rel homology domain (RHD) 547-639 Ankyrin repeats (3 copies) 583-612 Ankyrin repeat 583-609 Ankyrin repeat 615-637 Ankyrin repeat 619-710 Ankyrin repeats (3 copies) 650-680 Ankyrin repeat 652-705 Ankyrin repeats (many copies) 718-749 Ankyrin repeat 818-891 Death domain |
Sequence: (in bold interface residues) | 1 MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV 60 61 CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED 120 121 GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA 180 181 EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY 240 241 DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF 300 301 SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ 360 361 RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH 420 421 PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE 480 481 VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD 540 541 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 600 601 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM 660 661 SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT 720 721 TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT 780 781 SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG 840 841 LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ 900 901 AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ 960 961 EGPLEGKI |
Interface Residues: | 56, 58, 59, 61, 62, 64, 65, 66, 243, 245, 274, 307 |
3D-footprint Homologues: | 2ram_A, 1gji_A, 7cli_B, 1nfk_A, 2o61_A, 1a3q_A |
Binding Motifs: | MA0105.4 AGGGGAwTCCCCt MA0105.3 kGGraTTYCCm NFKB1_HUMAN.H10MO.B|M01366 gGGrAAkyCCC MA0105.1 GGGrmTTyCC MA0105.2 GGGGrwyYCCC |
Binding Sites: | MA0105.1.12 MA0105.1.10 / MA0105.1.4 / MA0105.1.5 / MA0105.1.6 / MA0105.1.7 / MA0105.1.8 / MA0105.1.9 MA0105.1.13 / MA0105.1.14 / MA0105.1.15 MA0105.1.17 MA0105.1.1 / MA0105.1.2 / MA0105.1.3 MA0105.1.16 MA0105.1.20 MA0105.1.19 MA0105.1.11 MA0105.1.18 MA0105.2.1 MA0105.2.10 MA0105.2.11 MA0105.2.12 MA0105.2.13 MA0105.2.14 MA0105.2.15 MA0105.2.16 MA0105.2.17 MA0105.2.18 MA0105.2.2 MA0105.2.3 MA0105.2.4 MA0105.2.5 MA0105.2.6 MA0105.2.7 MA0105.2.8 MA0105.2.9 MA0105.3.1 MA0105.3.10 MA0105.3.11 MA0105.3.12 / MA0105.3.13 MA0105.3.14 MA0105.3.15 MA0105.3.16 MA0105.3.17 MA0105.3.18 MA0105.3.19 MA0105.3.2 MA0105.3.20 MA0105.3.3 MA0105.3.4 MA0105.3.5 MA0105.3.6 MA0105.3.7 MA0105.3.8 MA0105.3.9 |
Publications: | Kunsch C., Ruben S. M., Rosen C. A. Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412-4421 (1992). [Pubmed] Grilli M., Chiu J. J.-S., Lenardo M. J. NF-kappaB and Rel: Participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1-62 (1993). [Pubmed] Wan F, Lenardo MJ. Specification of DNA binding activity of NF-kappaB proteins. Cold Spring Harb Perspect Biol : (2009). [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.