Transcription Factor
| Accessions: | ZNF273 (humanC2H2ZF-ChIP Feb2015), Q14593 (JASPAR 2024) |
| Names: | ENSG00000198039, Q14593, ZNF273, Zinc finger protein 273, Zinc finger protein HZF9, ZN273_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 569 |
| Pfam Domains: | 37-77 KRAB box 194-214 Zinc-finger double domain 221-244 Zinc-finger double domain 234-253 C2H2-type zinc finger 234-256 Zinc finger, C2H2 type 234-255 C2H2-type zinc finger 248-272 Zinc-finger double domain 261-282 C2H2-type zinc finger 262-284 Zinc finger, C2H2 type 262-284 C2H2-type zinc finger 277-300 Zinc-finger double domain 289-309 C2H2-type zinc finger 290-312 C2H2-type zinc finger 290-312 Zinc finger, C2H2 type 305-328 Zinc-finger double domain 318-340 Zinc finger, C2H2 type 318-340 C2H2-type zinc finger 318-337 C2H2-type zinc finger 333-356 Zinc-finger double domain 345-366 C2H2-type zinc finger 346-368 Zinc finger, C2H2 type 346-368 C2H2-type zinc finger 361-384 Zinc-finger double domain 373-396 C2H2-type zinc finger 374-396 Zinc finger, C2H2 type 374-396 C2H2-type zinc finger 389-413 Zinc-finger double domain 401-422 C2H2-type zinc finger 402-422 Zinc finger, C2H2 type 402-421 C2H2-type zinc finger 417-440 Zinc-finger double domain 429-449 C2H2-type zinc finger 430-452 Zinc finger, C2H2 type 430-452 C2H2-type zinc finger 445-467 Zinc-finger double domain 457-480 C2H2-type zinc finger 458-480 Zinc finger, C2H2 type 458-480 C2H2-type zinc finger 473-496 Zinc-finger double domain 485-506 C2H2-type zinc finger 486-508 Zinc finger, C2H2 type 486-508 C2H2-type zinc finger 501-524 Zinc-finger double domain 513-534 C2H2-type zinc finger 514-536 C2H2-type zinc finger 514-536 Zinc finger, C2H2 type 528-551 Zinc-finger double domain 545-566 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MSSAPRGPPSVAPLPAGIGRSTAKTPGLPGSLEMGPLTFRDVAIEFSLEEWQCLDTSQQN 60 61 LYRNVMLDNYRNLVFLGIAVSKPDLITCLEQGKEPCNMKRHAMVAKPPVVCSHFAQDLWP 120 121 KQGLKDSFQKVILRRYGKYGHENLQLRKGCKSADEHKVHKRGYNGLNQCLTTTQSKIFQC 180 181 DKYVKVLHKFSNSNIHKKRQTGKKPFKCKECGKSCCILSQLTQHKKTATRVNFYKCKTCG 240 241 KAFNQFSNLTKHKIIHPEVNPYKCEECGKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFS 300 301 VFSVLTKHKIIHTGTKPYNCEECGKGFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSST 360 361 LTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKH 420 421 KRIYTKEKPYKCEECGKAFSVFSTLTKHKIIHTGAKPYKCEECGSAFRAFSTLTEHKRVH 480 481 TGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNRSSNLTRHKKIHTGEK 540 541 PYKPKRCDSAFDNTPNFSRHKRNHMGEKS |
| Interface Residues: | 245, 247, 251, 272, 276, 301, 302, 303, 304, 307, 311, 318, 329, 330, 331, 332, 334, 335, 337, 338, 341, 356, 357, 358, 359, 360, 362, 363, 384, 385, 386, 387, 388, 390, 391, 412, 413, 414, 415, 416, 419, 422, 423, 441, 442, 443, 444, 447, 453, 467, 468, 469, 470, 471, 472, 475, 479, 496, 497, 498, 499, 500, 501, 503, 504, 524, 525, 526, 527, 528, 529, 530, 531, 532 |
| 3D-footprint Homologues: | 7w1m_H, 6wmi_A, 8ssq_A, 8ssu_A, 2kmk_A, 6ml4_A, 5v3j_F, 7ysf_A, 2jpa_A, 3uk3_C, 1tf3_A, 1tf6_A, 2i13_A, 1mey_C, 5und_A, 1g2f_F, 2lt7_A, 1ubd_C, 6u9q_A, 5yel_A, 5kkq_D, 6e94_A, 5ei9_F, 7eyi_G, 6jnm_A, 7n5w_A, 4x9j_A, 5kl3_A, 5k5i_A, 2gli_A, 8h9h_G, 6blw_A, 6a57_A, 8cuc_F, 7y3l_A, 1llm_D, 7txc_E, 2wbs_A, 2drp_D, 1f2i_J, 8gn3_A, 4m9v_C, 7y3m_I, 5yj3_D |
| Binding Motifs: | ZNF273_ChIP arCAGCTGC UN0607.1 GsrGCysCwGcy |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.