Transcription Factor

						

			
Accessions: NFAC2_HUMAN (HOCOMOCO 10), Q13469 (JASPAR 2024)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens, Rattus norvegicus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q13469
Length: 925
Pfam Domains:   410-570 Rel homology domain (RHD)
  589-675 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAY   60
  61 PDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHE  120
 121 LIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFIS  180
 181 DTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPR  240
 241 PASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGS  300
 301 AVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGER  360
 361 RNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHH  420
 421 RAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRIT  480
 481 GKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNT  540
 541 RVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTG  600
 601 QNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYV  660
 661 INGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSC  720
 721 LVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADA  780
 781 HRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPG  840
 841 TTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNL  900
 901 DQTYLDDVNEIIRKEFSGPPARNQT
Interface Residues: 421, 423, 424, 426, 427, 430, 520, 537, 571, 572, 664, 665
3D-footprint Homologues: 1p7h_L, 1a66_A, 1imh_C
Binding Motifs: MA0152.1 TTTTCCA
NFAC2_HUMAN.H10MO.B|M01357 wGGAAAAwt
Binding Sites: MA0152.1.1
MA0152.1.10
MA0152.1.11
MA0152.1.12
MA0152.1.13
MA0152.1.14
MA0152.1.15
MA0152.1.16
MA0152.1.17
MA0152.1.18
MA0152.1.19
MA0152.1.2
MA0152.1.20
MA0152.1.3
MA0152.1.4
MA0152.1.5
MA0152.1.6
MA0152.1.7
MA0152.1.8
MA0152.1.9
			
Publications: Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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