Transcription Factor
| Accessions: | Q9UBP5 (JASPAR 2024) |
| Names: | bHLHb32, Cardiovascular helix-loop-helix factor 1, Class B basic helix-loop-helix protein 32, Hairy and enhancer of split-related protein 2, Hairy-related transcription factor 2, Hairy/enhancer-of-split related with YRPW motif protein 2, hCHF1, HES-related repressor protein 2, HESR-2, HEY2_HUMAN, hHRT2, HRT-2, Protein gridlock homolog |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UBP5 |
| Length: | 337 |
| Pfam Domains: | 53-104 Helix-loop-helix DNA-binding domain 123-163 Hairy Orange |
| Sequence: (in bold interface residues) | 1 MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRR 60 61 RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMD 120 121 FMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPL 180 181 HPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRM 240 241 PSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAA 300 301 TAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF |
| Interface Residues: | 50, 52, 53, 54, 56, 57, 60, 61, 87, 89 |
| 3D-footprint Homologues: | 7z5k_B, 1an4_A, 6g1l_A, 5eyo_A, 1am9_A, 5sy7_B, 7d8t_A, 4h10_B, 7f2f_B, 8osl_O, 7ssa_L, 2ql2_D, 7xi3_A, 4h10_A, 5gnj_I, 5v0l_A, 4zpk_A, 1a0a_B, 5nj8_D, 2ypa_A, 8osl_P, 5nj8_C, 5v0l_B |
| Binding Motifs: | MA0649.1 GrCACGTGyc MA0649.2 GrCACGTGy |
| Publications: | Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M. Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet : (2012;8(5):e1002728.). [Pubmed] |
| Related annotations: | PaperBLAST |
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