Transcription Factor

Accessions: ZNF45 (humanC2H2ZF-ChIP Feb2015), Q02386 (JASPAR 2024)
Names: ENSG00000124459, Q02386, ZNF45, BRC1744, Zinc finger protein 13, Zinc finger protein 45, Zinc finger protein KOX5, ZNF45_HUMAN
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC
Length: 682
Pfam Domains: 8-48 KRAB box
184-202 Zinc-finger double domain
191-215 C2H2-type zinc finger
192-214 C2H2-type zinc finger
192-214 Zinc finger, C2H2 type
268-286 Zinc-finger double domain
276-298 Zinc finger, C2H2 type
276-298 C2H2-type zinc finger
291-314 Zinc-finger double domain
303-317 C2H2-type zinc finger
304-326 C2H2-type zinc finger
304-326 Zinc finger, C2H2 type
319-343 Zinc-finger double domain
331-343 C2H2-type zinc finger
332-354 C2H2-type zinc finger
332-354 Zinc finger, C2H2 type
346-370 Zinc-finger double domain
359-382 C2H2-type zinc finger
360-382 C2H2-type zinc finger
360-382 Zinc finger, C2H2 type
374-397 Zinc-finger double domain
387-410 C2H2-type zinc finger
388-410 C2H2-type zinc finger
388-410 Zinc finger, C2H2 type
402-426 Zinc-finger double domain
416-431 C2H2-type zinc finger
416-438 C2H2-type zinc finger
416-438 Zinc finger, C2H2 type
431-454 Zinc-finger double domain
443-466 C2H2-type zinc finger
444-466 C2H2-type zinc finger
444-466 Zinc finger, C2H2 type
458-482 Zinc-finger double domain
471-490 C2H2-type zinc finger
472-494 C2H2-type zinc finger
472-494 Zinc finger, C2H2 type
486-510 Zinc-finger double domain
499-522 C2H2-type zinc finger
500-522 Zinc finger, C2H2 type
500-522 C2H2-type zinc finger
514-538 Zinc-finger double domain
528-548 Zinc finger, C2H2 type
528-550 C2H2-type zinc finger
543-565 Zinc-finger double domain
556-578 Zinc finger, C2H2 type
556-575 C2H2-type zinc finger
570-594 Zinc-finger double domain
584-606 C2H2-type zinc finger
584-606 Zinc finger, C2H2 type
584-606 C2H2-type zinc finger
599-622 Zinc-finger double domain
611-629 C2H2-type zinc finger
612-634 C2H2-type zinc finger
612-634 Zinc finger, C2H2 type
627-650 Zinc-finger double domain
639-662 C2H2-type zinc finger
640-662 C2H2-type zinc finger
640-662 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MTKSKEAVTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVGHQSTPDGLPQLE 60
61 REEKLWMMKMATQRDNSSGAKNLKEMETLQEVGLRYLPHEELFCSQIWQQITRELIKYQD 120
121 SVVNIQRTGCQLEKRDDLHYKDEGFSNQSSHLQVHRVHTGEKPYKGEHCVKSFSWSSHLQ 180
181 INQRAHAGEKPYKCEKCDNAFRRFSSLQAHQRVHSRAKSYTNDASYRSFSQRSHLPHHQR 240
241 VPTGENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTG 300
301 KKPYKCEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFSYSSHLNIHCRIHTGEKPY 360
361 KCEECGKGFSVGSHLQAHQISHTGEKPYKCEECGKGFCRASNLLDHQRGHTGEKPYQCDA 420
421 CGKGFSRSSDFNIHFRVHTGEKPYKCEECGKGFSQASNLLAHQRGHTGEKPYKCGTCGKG 480
481 FSRSSDLNVHCRIHTGEKPYKCERCGKAFSQFSSLQVHQRVHTGEKPYQCAECGKGFSVG 540
541 SQLQAHQRCHTGEKPYQCEECGKGFCRASNFLAHRGVHTGEKPYRCDVCGKRFRQRSYLQ 600
601 AHQRVHTGERPYKCEECGKVFSWSSYLQAHQRVHTGEKPYKCEECGKGFSWSSSLIIHQR 660
661 VHADDEGDKDFPSSEDSHRKTR
Interface Residues: 214, 215, 262, 287, 288, 289, 290, 291, 292, 293, 295, 297, 301, 314, 315, 317, 318, 321, 343, 345, 346, 348, 349, 371, 372, 373, 374, 376, 377, 379, 380, 383, 388, 399, 400, 401, 402, 405, 426, 427, 428, 429, 430, 433, 454, 455, 456, 457, 458, 461, 482, 483, 484, 485, 486, 488, 489, 510, 511, 512, 513, 514, 515, 516, 517, 538, 539, 540, 541, 542, 544, 545, 566, 567, 568, 569, 570, 573, 575, 594, 595, 596, 597, 598, 601, 602, 604, 607, 621, 623, 624, 625, 626, 627, 629, 630, 633, 650, 651, 652, 653, 654, 656, 657
3D-footprint Homologues: 6dnw_A, 8gn3_A, 1ubd_C, 8cuc_F, 6wmi_A, 5v3j_F, 2lt7_A, 8ssq_A, 2i13_A, 6blw_A, 5kkq_D, 5ei9_F, 5yj3_D, 2jpa_A, 2kmk_A, 5und_A, 7w1m_H, 1llm_D, 5yel_A, 5k5l_F, 4x9j_A, 2wbs_A, 1f2i_J, 5k5i_A, 7n5w_A, 2gli_A, 1g2f_F, 8ssu_A, 1mey_C, 2drp_D, 6u9q_A, 8h9h_G, 7eyi_G, 6e94_A, 7ysf_A, 3uk3_C, 6ml4_A, 7y3l_A, 7y3m_I, 1tf3_A, 1tf6_A, 6jnm_A, 5kl3_A, 4m9v_C, 6a57_A, 7txc_E
Binding Motifs: ZNF45_ChIP ATAACArAATCCAGa
UN0325.1 svrCCGGAAGTGrcgbss
UN0325.2 CCGGAAGTG
Binding Sites: UN0325.1.1
UN0325.1.10
UN0325.1.11
UN0325.1.12
UN0325.1.13
UN0325.1.14
UN0325.1.15
UN0325.1.16
UN0325.1.17
UN0325.1.18
UN0325.1.19
UN0325.1.2
UN0325.1.20
UN0325.1.3
UN0325.1.4
UN0325.1.5
UN0325.1.6
UN0325.1.7
UN0325.1.8
UN0325.1.9
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.