Transcription Factor

						

			
Accessions: Q96A47 (JASPAR 2024)

			
Names: Insulin gene enhancer protein ISL-2, ISL2_HUMAN, Islet-2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q96A47
Length: 359
Pfam Domains:     27-85 LIM domain
   89-143 LIM domain
  193-248 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ   60
  61 YLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVC  120
 121 SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPAL  180
 181 RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ  240
 241 NKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP  300
 301 WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET
Interface Residues: 186, 188, 192, 193, 194, 195, 233, 234, 236, 237, 240, 241, 244, 245, 248
3D-footprint Homologues: 4cyc_A, 2r5y_A, 3d1n_M, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 1nk2_P, 7psx_B, 1b72_A, 5hod_A, 2ld5_A, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 3rkq_B, 4xrs_G, 2hdd_A, 5zfz_A, 5flv_I, 3l1p_A, 2hos_A, 1fjl_B, 5jlw_D, 1le8_A, 7q3o_C, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1o4x_A, 4xrm_B, 1le8_B, 1du0_A, 1puf_A, 6es3_K, 1mnm_C, 1puf_B, 1k61_B, 8g87_X, 5zjt_E, 4qtr_D
Binding Motifs: MA0914.1 gCAmTTAr
MA0914.2 CAmTTA
			
Publications: Gong Z., Hew C. L. Zinc and DNA binding properties of a novel LIM homeodomain protein Isl-2.. Biochemistry 33:15149-15158 (1994). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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