Transcription Factor
| Accessions: | BHLHE23_DBD (HumanTF 1.0), BHLHE23 (HT-SELEX2 May2017) |
| Names: | BHE23_HUMAN, bHLHb4, BHLHE23, Class B basic helix-loop-helix protein 4, Class E basic helix-loop-helix protein 23, ENSG00000125533 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q8NDY6 |
| Notes: | Ensembl ID: ENSG00000125533; DNA-binding domain sequence; TF family: bHLH; Clone source: Gene synthesis, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 4b0, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4b0 |
| Length: | 107 |
| Pfam Domains: | 29-79 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 DAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSP 60 61 SVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAAPVNA |
| Interface Residues: | 29, 32, 33, 35, 36, 37, 39, 40, 65 |
| 3D-footprint Homologues: | 2ypa_A, 6od3_F, 7d8t_A, 2ql2_A, 2ql2_D, 2ypa_B, 1an4_A, 4h10_A, 8osl_P, 6g1l_A |
| Binding Motifs: | BHLHE23_DBD AmCATATGyy BHLHE23_2 amCATATGky BHLHE23_4 rsCATATGkY BHLHE23_methyl_1 AmCATATGky BHLHE23_methyl_3 RmCATATGgT |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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