Transcription Factor

Accessions: P31245 (JASPAR 2024)
Names: Homeobox protein Hox-1.11, Homeobox protein Hox-A2, Hox1.11, HXA2_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 372
Pfam Domains: 140-196 Homeobox domain
Sequence:
(in bold interface residues)
1 MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLN 60
61 PGSHPRHGAGVGGRPKSSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALPPAAASTGP 120
121 ACLGHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTE 180
181 RQVKVWFQNRRMKHKRQTQCKENQNSEGKFKNLEDSDKVEEDEEEKSLFEQALSVSGALL 240
241 EREGYTFQQNALSQQQAPNGHNGDSQTFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQN 300
301 CGAGLNNDSPEAIEVPSLQDFNVFSTDSCLQLSDALSPSLPGSLDSPVDISADSFDFFTD 360
361 TLTTIDLQHLNY
Interface Residues: 140, 141, 142, 143, 181, 182, 184, 185, 188, 189, 192, 193, 196
3D-footprint Homologues: 1fjl_B, 3d1n_M, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 3rkq_B, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 1ig7_A, 7psx_B, 5hod_A, 3l1p_A, 3a01_E, 5jlw_D, 4xrs_G, 2hdd_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 1au7_A, 8g87_X, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: PH0049.1 amggTAATTAscymAd
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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