Transcription Factor

Accessions: T012466_1.02 (CISBP 1.02), Q9FUA4 (JASPAR 2024)
Names: SPT, T012466_1.02;, AtbHLH24, Basic helix-loop-helix protein 24, bHLH 24, bHLH transcription factor bHLH024, SPT_ARATH, Transcription factor EN 99, Transcription factor SPATULA
Organisms: Arabidopsis thaliana
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:bHLH
Length: 373
Pfam Domains: 201-247 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MISQREEREEKKQRVMGDKKLISSSSSSSVYDTRINHHLHHPPSSSDEISQFLRHIFDRS 60
61 SPLPSYYSPATTTTTASLIGVHGSGDPHADNSRSLVSHHPPSDSVLMSKRVGDFSEVLIG 120
121 GGSGSAAACFGFSGGGNNNNVQGNSSGTRVSSSSVGASGNETDEYDCESEEGGEAVVDEA 180
181 PSSKSGPSSRSSSKRCRAAEVHNLSEKRRRSRINEKMKALQSLIPNSNKTDKASMLDEAI 240
241 EYLKQLQLQVQMLTMRNGINLHPLCLPGTTLHPLQLSQIRPPEATNDPLLNHTNQFASTS 300
301 NAPEMINTVASSYALEPSIRSHFGPFPLLTSPVEMSREGGLTHPRLNIGHSNANITGEQA 360
361 LFDGQPDLKDRIT
Interface Residues: 202, 203, 205, 206, 209, 210, 230, 232
3D-footprint Homologues: 6g1l_A, 5eyo_A, 7xi3_A, 5nj8_D, 4h10_A, 7d8t_A, 5gnj_I, 1a0a_B, 8osl_O, 5v0l_A, 7f2f_B, 5i50_B, 1am9_A, 4zpk_A, 7ssa_L, 4h10_B, 8osl_P, 1an4_A, 5nj8_C, 5v0l_B
Binding Motifs: M0162_1.02 csCACGTGc
MA1061.1 csCACGTGc
MA1061.2 sCACGTG
Publications: Fernández-Calvo P, Chini A, Fernández-Barbero G, Chico J.M, Gimenez-Ibanez S, Geerinck J, Eeckhout D, Schweizer F, Godoy M, Franco-Zorrilla J.M, Pauwels L, Witters E, Puga M.I, Paz-Ares J, Goossens A, Reymond P, De Jaeger G, Solano R. The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. The Plant cell 23:701-15 (2011). [Pubmed]
Related annotations: PaperBLAST

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