Transcription Factor
| Accessions: | PRRX2_MOUSE (HOCOMOCO 10), Q06348 (JASPAR 2024) |
| Names: | Homeobox protein S8, Paired mesoderm homeobox protein 2, PRRX2_MOUSE, PRX-2 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 247 |
| Pfam Domains: | 99-155 Homeobox domain 221-239 OAR domain |
| Sequence: (in bold interface residues) | 1 MDSAAAAFALDPPAPGPGPPPAPGDCAQARKNFSVSHLLDLEEVAAAGRRAAGPVSGPAE 60 61 ARVGAAREPSGGSSGTEAAPQDGDCPSPGRGTKRKKKQRRNRTTFNSSQLQALERVFERT 120 121 HYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLATRSASLLKSYGQEAAIEQ 180 181 PVAPRPTTMSPDYLSWPASSPYSSVPPYSPGGSSPATPGVNMANSIASLRLKAKEFSLHH 240 241 SQVPTVN |
| Interface Residues: | 98, 99, 100, 101, 102, 140, 141, 143, 144, 147, 148, 151, 152, 155 |
| 3D-footprint Homologues: | 4j19_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | MA0075.2 yyAATTAr MA0075.1 AATTA PRRX2_MOUSE.H10MO.C|M01311 yTAATTr PH0155.1 wvmrYTAATTARygrwr |
| Binding Sites: | MA0075.1.1 MA0075.1.10 MA0075.1.11 MA0075.1.12 MA0075.1.13 MA0075.1.14 MA0075.1.15 MA0075.1.16 MA0075.1.17 MA0075.1.18 MA0075.1.19 MA0075.1.2 MA0075.1.20 MA0075.1.3 MA0075.1.4 MA0075.1.5 MA0075.1.6 MA0075.1.7 MA0075.1.8 MA0075.1.9 |
| Publications: | de Jong R., van der Heijden J., Meijlink F. DNA-binding specificity of the S8 homeodomain. Nucleic Acids Res. 21:4711-4720 (1993). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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