Transcription Factor
| Accessions: | UP00584D (UniPROBE 20160601) |
| Names: | Aristaless-related homeobox, ARX_P353R, CT121, EIEE1, homeobox protein ARX, ISSX, MRX29, MRX32, MRX33, MRX36, MRX38, MRX43, MRX54, MRX76, MRX87, MRXS1, PRTS |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein ARX: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate. |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 AGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYRDVFTREELAMRLDLTEARVQV 60 61 WFQNRRAKWRKREKAGAQTHPPGLPF |
| Interface Residues: | 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 70, 71 |
| 3D-footprint Homologues: | 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 1nk2_P, 5zfz_A, 2h1k_B, 3lnq_A, 2lkx_A, 1zq3_P, 1jgg_B, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 7psx_B, 1au7_A, 5hod_A, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1k61_B, 4qtr_D, 1du0_A, 1o4x_A, 8g87_X |
| Binding Motifs: | UP00584D_1 Trrkdgbayaattrtwrmtwdw UP00584D_2 smysmwatrtryayatrkAwkwd |
| Binding Sites: | ACATGTAC ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAG ATAATTAT ATATTATG ATCATATG ATGCATCA CAATTATC CATAATTA CATACATG CATTAATG CCAATTAG CTAATTAA CTAATTAG GATAATTA GCTAATTA GTAATTAC TAATATTA TAATTATA TTAATTAA ACAGTACA ACATACAT ACATATCA ACATCATA ACTGTTAC ATAACACA ATACATAT ATATACAC ATATAGTA ATCATCAT ATGATGTA CACATTAC GTATGATA TACATACA TACATATA TATACACA TATATACA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.