Transcription Factor
| Accessions: | T100208_1.02 (CISBP 1.02), UP00459A (UniPROBE 20160601), P0CY08 (JASPAR 2024) |
| Names: | MATALPHA2, T100208_1.02;, Hidden Mat Left ALPHA, Hmlalpha2, Alpha-2 repressor, MATalpha2 protein, Mating-type protein ALPHA2, MTAL2_YEAST |
| Organisms: | Saccharomyces cerevisiae, Saccharomyces cerevisiae S288c |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Hidden Mat Left ALPHA : Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 210 |
| Pfam Domains: | 135-188 Homeobox domain 147-185 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MNKIPIKDLLNPQITDEFKSSILDINKKLFSICCNLPKLPESVTTEEEVELRDILGFLSR 60 61 ANKNRKISDEEKKLLQTTSQLTTTITVLLKEMRSIENDRSNYQLTQKNKSADGLVFNVVT 120 121 QDMINKSTKPYRGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWV 180 181 SNRRRKEKTITIAPELADLLSGEPLAKKKE |
| Interface Residues: | 130, 132, 133, 134, 135, 174, 175, 177, 178, 181, 182, 185, 186, 188, 189 |
| 3D-footprint Homologues: | 2lkx_A, 3d1n_M, 1mnm_C, 1k61_B, 1le8_B, 4j19_B, 2ld5_A, 1ig7_A, 7q3o_C, 7xrc_C, 2xsd_C, 6fqp_B, 3a01_E, 1puf_B, 4xrm_B, 6fqq_E, 3cmy_A, 1zq3_P, 5zjt_E, 2hdd_A, 1du0_A, 6es3_K, 7psx_B, 2hos_A, 6m3d_C |
| Binding Motifs: | MA0328.1 CATGTAAwT M1129_1.02 waaACAAT MA0328.2 CrTGTAaw UP00459A_1 / UP00459A_2 grtrahswTTACAyRwtwtmsy UP00459A_3 CATGTTGA |
| Binding Sites: | AACATGTA AATTACAT ACATGTAA ATTACATG CATGTAAA CATGTTAA ATTACACA ATTACACG ATTACATA CCATGTAA CCGTGTAA CGTGTAAA CTATGTAA CTTTACAC GATTACAC GCATGTAA GCGTGTAA TATGTAAA TCGTGTAA TGTGTAAA |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] Zhu J, Zhang M.Q. SCPD: a promoter database of the yeast Saccharomyces cerevisiae. Bioinformatics (Oxford, England) 15:607-11 (). [Pubmed] Jin Y, Zhong H, Vershon AK. The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding. Mol Cell Biol 19:585-93 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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