Transcription Factor

						

			
Accessions: Q8TAK6 (JASPAR 2024)

			
Names: bHLHb6, bHLHe21, Class B basic helix-loop-helix protein 6, Class E basic helix-loop-helix protein 21, OLIG1_HUMAN, Oligo1, Oligodendrocyte transcription factor 1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q8TAK6
Length: 271
Pfam Domains:   107-164 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSST   60
  61 TAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQLRRKINSRERKRMQD  120
 121 LNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAG  180
 181 PAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGAG  240
 241 GPGLCTCAVCKFPHLVPASLGLAAVQAQFSK
Interface Residues: 111, 113, 114, 117, 118
3D-footprint Homologues: 2ql2_D, 2ypa_A, 2ypa_B
Binding Motifs: MA0826.1 AmCATATGkT
			
Publications: Küspert M, Hammer A, Bösl MR, Wegner M. Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Res 39:1280-93 (2011). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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