Transcription Factor

Accessions: Q9C056 (JASPAR 2024)
Names: Homeobox protein NK-6 homolog B, Homeobox protein Nkx-6.2, NKX62_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9C056
Length: 277
Pfam Domains: 149-205 Homeobox domain
Sequence:
(in bold interface residues)
1 MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGI 60
61 SDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPG 120
121 VVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERAR 180
181 LAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDDDEYNR 240
241 PLDPNSDDEKITRLLKKHKPSNLALVSPCGGGAGDAL
Interface Residues: 148, 149, 150, 151, 152, 154, 190, 191, 193, 194, 197, 198, 201, 202, 205, 206, 215, 218
3D-footprint Homologues: 4j19_B, 1puf_A, 2ld5_A, 2h1k_B, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 1zq3_P, 2lkx_A, 1nk2_P, 7q3o_C, 6es3_K, 1jgg_B, 6wig_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 3lnq_A, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 4cyc_A, 1mnm_C, 1e3o_C, 1le8_A, 1au7_A, 7xrc_C, 2xsd_C, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A
Binding Motifs: MA0675.1 symATTAa
MA0675.2 ymATTA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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