Transcription Factor
| Accessions: | BCL6_MOUSE (HOCOMOCO 10), P41183 (JASPAR 2024) |
| Names: | BCL6_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P41183 |
| Length: | 707 |
| Pfam Domains: | 22-128 BTB/POZ domain 547-569 C2H2-type zinc finger 561-585 Zinc-finger double domain 575-597 Zinc finger, C2H2 type 575-594 C2H2-type zinc finger 575-595 Zinc-finger of C2H2 type 589-613 Zinc-finger double domain 603-625 C2H2-type zinc finger 617-642 Zinc-finger double domain 631-653 C2H2-type zinc finger 631-653 Zinc finger, C2H2 type 633-652 Zinc-finger of C2H2 type 646-669 Zinc-finger double domain 659-682 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI 60 61 FTDQLKCNLSVINLDPEISPEGFCILLDFMYTSRLNLREGNIMAVMTTAMYLQMEHVVDT 120 121 CRKFIKASEAEMAPALKPPREEFLNSRMLMPHDIMAYRGREVVENNMPLRNTPGCESRAF 180 181 APPLYSGLSTPPASYPMYSHLPLSTFLFSDEELRDAPRMPVANPFPKERALPCDSARQVP 240 241 NEYSRPAMEVSPSLCHSNIYSPKEAVPEEARSDIHYSVPEGPKPAVPSARNAPYFPCDKA 300 301 SKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQAS 360 361 GSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGSEQAELGRLSPRAYPAPPACQPPME 420 421 PANLDLQSPTKLSASGEDSTIPQASRLNNLVNRSLAGSPRSSSESHSPLYMHPPKCTSCG 480 481 SQSPQHTEMCLHTAGPTFPEEMGETQSEYSDSSCENGTFFCNECDCRFSEEASLKRHTLQ 540 541 THSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGE 600 601 KPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYH 660 661 CEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSAADLPPELPKAC |
| Interface Residues: | 530, 532, 533, 536, 557, 558, 559, 560, 561, 563, 564, 566, 567, 568, 570, 575, 585, 586, 587, 588, 589, 591, 592, 595, 596, 613, 614, 615, 616, 617, 619, 620, 624, 641, 642, 643, 644, 645, 646, 647, 648, 649, 651, 669, 670, 671, 672, 673, 674, 675, 676, 677 |
| 3D-footprint Homologues: | 5v3j_F, 2i13_A, 6wmi_A, 7w1m_H, 5k5l_F, 1tf6_A, 5yel_A, 1ubd_C, 7n5w_A, 8cuc_F, 7y3l_A, 8gn3_A, 5kkq_D, 1mey_C, 5kl3_A, 8ssq_A, 8ssu_A, 6ml4_A, 8h9h_G, 7eyi_G, 6blw_A, 2jpa_A, 2kmk_A, 1tf3_A, 6jnm_A, 4x9j_A, 1llm_D, 6u9q_A, 5ei9_F, 5k5i_A, 5und_A, 2gli_A, 1g2f_F, 7y3m_I, 6e94_A, 7ysf_A, 2lt7_A, 7txc_E, 2drp_D, 1f2i_J, 5yj3_D, 6a57_A, 3uk3_C, 2wbs_A, 4m9v_C |
| Binding Motifs: | MA0463.1 kTTCCTrGAaagca BCL6_MOUSE.H10MO.C|M01021 wTTCCTrGArAgc |
| Binding Sites: | MA0463.1.1 MA0463.1.10 MA0463.1.11 MA0463.1.12 MA0463.1.13 MA0463.1.14 MA0463.1.15 MA0463.1.16 MA0463.1.17 MA0463.1.18 MA0463.1.19 MA0463.1.2 MA0463.1.20 MA0463.1.3 MA0463.1.4 MA0463.1.5 MA0463.1.6 MA0463.1.7 MA0463.1.8 MA0463.1.9 |
| Publications: | Kawamata N., Miki T., Ohashi K., Suzuki K., Fukuda T., Hirosawa S., Aoki N. Recognition DNA sequence of a novel putative transcription factor, BCL6.. Biochem. Biophys. Res. Commun. 204:366-374 (1994). [Pubmed] Chang C.-C., Ye B. H., Chaganti R. S. K., Dalla-Favera R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 93:6947-6952 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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