Transcription Factor

Accessions: ftz (DrosophilaTF 1.1), P02835 (JASPAR 2024)
Names: FTZ_DROME
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, JASPAR 2024 2
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P02835
Length: 410
Pfam Domains: 1-248 Fushi tarazu (FTZ), N-terminal region
255-311 Homeobox domain
Sequence:
(in bold interface residues)
1 MATTNSQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESC 60
61 YYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKL 120
121 KYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQT 180
181 QKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNW 240
241 SHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKI 300
301 WFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAY 360
361 PAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQQHPQDLYHLS
Interface Residues: 239, 255, 256, 257, 258, 259, 296, 297, 299, 300, 303, 304, 307, 308, 311
3D-footprint Homologues: 1e3o_C, 1ig7_A, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 2lkx_A, 1jgg_B, 6m3d_C, 1zq3_P, 3lnq_A, 7q3o_C, 6es3_K, 1nk2_P, 2ld5_A, 3a01_E, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 1puf_B, 1au7_A, 5flv_I, 2hos_A, 5zjt_E, 4j19_B, 7psx_B, 1b72_A, 7xrc_C, 2xsd_C, 1le8_A, 4qtr_D, 1le8_B, 1du0_A, 1mnm_C, 1k61_B, 3l1p_A, 8g87_X, 5hod_A, 1o4x_A
Binding Motifs: MA0225.1 TTAATkA
ftz rcryTAATGrcmt
Binding Sites: MA0225.1.20
MA0225.1.10
MA0225.1.15
MA0225.1.3
MA0225.1.1
MA0225.1.11
MA0225.1.12
MA0225.1.13
MA0225.1.14
MA0225.1.16
MA0225.1.17
MA0225.1.18
MA0225.1.19
MA0225.1.2
MA0225.1.4
MA0225.1.5
MA0225.1.6
MA0225.1.7
MA0225.1.8
MA0225.1.9
Publications: Wilson D.S, Sheng G, Jun S, Desplan C. Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proceedings of the National Academy of Sciences of the United States of America 93:6886-91 (1996). [Pubmed]

Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.