Transcription Factor

						

			
Accessions: TFAP4_HUMAN (HOCOMOCO 10), Q01664 (JASPAR 2024)

			
Names: Activating enhancer-binding protein 4, bHLHc41, Class C basic helix-loop-helix protein 41, TFAP4_HUMAN, Transcription factor AP-4
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q01664
Length: 338
Pfam Domains:    49-100 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQERRIRREIANSNERRR   60
  61 MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQEL  120
 121 SGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLE  180
 181 AHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAP  240
 241 PPPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKP  300
 301 VRSCPEAPTSDTASDSEASDSDAMDQSREEPSGDGELP
Interface Residues: 50, 52, 53, 54, 56, 57, 60, 61, 85
3D-footprint Homologues: 7z5k_B, 2ypa_A, 1an4_A, 5i50_B, 5eyo_A, 1am9_A, 2ypa_B, 2ql2_A, 7d8t_A, 2ql2_D, 6g1l_A, 5gnj_I, 7ssa_L
Binding Motifs: MA0691.1 AwCAGCTGwT
MA1966.1 rsCGGAwgCAGsTGgk
MA1967.1 acCGGAAACAGCTGwy
MA1570.1 ahCAyrTGkt
TFAP4_HUMAN.H10MO.C|M01569 ryCAGCTGygG
MA1966.2 sCGGAwgCAGsTG
MA1967.2 acCGGAAACAGCTG
			
Publications: Jung P, Menssen A, Mayr D, Hermeking H. AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 105:15046-51 (2008). [Pubmed]


Badinga L, Song S, Simmen RC, Simmen FA. A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4. Endocrine 8:281-9 (1998). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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