Transcription Factor

						

			
Accessions: O75360 (JASPAR 2024)

			
Names: Homeobox protein prophet of Pit-1, Pituitary-specific homeodomain factor, PROP-1, PROP1_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O75360
Length: 226
Pfam Domains:    70-126 Homeobox domain
   93-122 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MEAERRRQAEKPKKGRVGSNLLPERHPATGTPTTTVDSSAPPCRRLPGAGGGRSRFSPQG   60
  61 GQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNR  120
 121 RAKQRKQERSLLQPLAHLSPAAFSSFLPESTACPYSYAAPPPPVTCFPHPYSHALPSQPS  180
 181 TGGAFALSHQSEDWYPTLHPAPAGHLPCPPPPPMLPLSLEPSKSWN
Interface Residues: 69, 70, 71, 72, 73, 111, 112, 114, 115, 118, 119, 122, 123, 126, 129, 130
3D-footprint Homologues: 4j19_B, 1ig7_A, 5zfz_A, 2h1k_B, 1puf_A, 3cmy_A, 1mnm_C, 6a8r_A, 3d1n_M, 1fjl_B, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 6es3_K, 2ld5_A, 1le8_B, 1k61_B, 7q3o_C, 1b72_A, 4xrs_G, 3l1p_A, 3a01_E, 6m3d_C, 5flv_I, 5zjt_E, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 1au7_A, 2hos_A, 5jlw_D, 4cyc_A, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 1du0_A, 8g87_X, 4qtr_D, 4xrm_B
Binding Motifs: MA0715.1 TAATywAATTA
			
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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