Transcription Factor

						

			
Accessions: NFKB1 (SMILE-seq 1.0)

			
Names: E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, EC 2.3.2.27, Growth inhibition and death E3 ligase, MAPL, Mitochondrial ubiquitin ligase activator of NFKB 1, Mitochondrial-anchored protein ligase, MUL1_HUMAN, NFKB1, Putative NF-kappa-B-activating protein 266, RING finger protein 218, RING-type E3 ubiquitin transferase NFKB 1
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q969V5
Notes: TF family: ANK repeats
Length: 968
Pfam Domains:    45-243 Rel homology domain (RHD)
  548-640 Ankyrin repeats (3 copies)
  584-613 Ankyrin repeat
  584-610 Ankyrin repeat
  616-638 Ankyrin repeat
  620-711 Ankyrin repeats (3 copies)
  651-681 Ankyrin repeat
  653-706 Ankyrin repeats (many copies)
  719-750 Ankyrin repeat
  819-892 Death domain
Sequence: 
(in bold interface residues)		   1 MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRY   60
  61 VCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE  120
 121 DGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGHNPGLLVHPDLAYLQ  180
 181 AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAI  240
 241 YDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD  300
 301 FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEV  360
 361 QRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITF  420
 421 HPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNG  480
 481 EVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQ  540
 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE  600
 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM  660
 661 MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG  720
 721 TTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMA  780
 781 TSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKL  840
 841 GLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS  900
 901 QAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYG  960
 961 QEGPLEGK
Interface Residues: 57, 59, 60, 62, 63, 65, 66, 67, 244, 246, 275, 308
3D-footprint Homologues: 1nfk_A, 2o61_A, 1a3q_A, 2ram_A, 1gji_A, 7cli_B
Binding Motifs: NFKB1 rGGkrmttyCCCy
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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