Transcription Factor
| Accessions: | Q12947 (JASPAR 2024) |
| Names: | Forkhead box protein F2, Forkhead-related activator 2, Forkhead-related protein FKHL6, Forkhead-related transcription factor 2, FOXF2_HUMAN, FREAC-2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 444 |
| Pfam Domains: | 100-192 Fork head domain |
| Sequence: (in bold interface residues) | 1 MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSS 60 61 SSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKR 120 121 LTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS 180 181 EFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQ 240 241 GGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAA 300 301 GGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSN 360 361 PAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFH 420 421 PSASGSYYHHHHQSVCQDIKPCVM |
| Interface Residues: | 97, 140, 143, 145, 146, 147, 149, 150, 151, 153, 154, 163, 170, 194 |
| 3D-footprint Homologues: | 7yzb_A, 7yzg_A, 7yz7_A, 3l2c_A, 7vox_H, 2hdc_A, 6el8_A, 7tdx_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7tdw_A, 3g73_A, 3qrf_G |
| Binding Motifs: | MA0030.1 bmaasRTAAACAaw MA0030.2 sRTAAACAa |
| Binding Sites: | MA0030.1.1 MA0030.1.10 MA0030.1.11 MA0030.1.12 MA0030.1.13 MA0030.1.14 MA0030.1.15 MA0030.1.16 MA0030.1.17 MA0030.1.18 MA0030.1.19 MA0030.1.2 MA0030.1.20 MA0030.1.3 MA0030.1.4 MA0030.1.5 MA0030.1.6 MA0030.1.7 MA0030.1.8 MA0030.1.9 |
| Publications: | Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13:5002-5012 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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