Transcription Factor
| Accessions: | T095300_1.02 (CISBP 1.02), P02831 (JASPAR 2024) |
| Names: | Hoxa3, T095300_1.02;, Homeobox protein Hox-1.5, Homeobox protein Hox-A3, Homeobox protein MO-10, HXA3_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 443 |
| Pfam Domains: | 193-249 Homeobox domain 378-441 Domain of unknown function (DUF4074) |
| Sequence: (in bold interface residues) | 1 MQKATYYDSSAIYGGYPYQAANGFAYNASQQPYAPSAALGTDGVEYHRPACSLQSPASAG 60 61 GHPKTHELSEACLRTLSGPPSQPPGLGEPPLPPPPPQAAPPAPQPPQPPPQPPAPTPAAP 120 121 PPPSSVSPPQSANSNPTPASTAKSPLLNSPTVGKQIFPWMKESRQNTKQKTSGSSSGESC 180 181 AGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWF 240 241 QNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSK 300 301 PPQGAYGLPPASYPAPLPSCAPPPPPQKRYTAAGSGAGGTPDYDPHAHGLQGNGSYGTPH 360 361 LQGSPVFVGGSYVEPMSNSGPLFGLTHLPHTTSAAMDYGGTGPLGSGHHHGPGPGEPHPT 420 421 YTDLTAHHPSQGRIQEAPKLTHL |
| Interface Residues: | 184, 193, 194, 195, 196, 234, 235, 237, 238, 241, 242, 245, 246, 249 |
| 3D-footprint Homologues: | 3a01_E, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 1ig7_A, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 3d1n_M, 1o4x_A, 1du0_A |
| Binding Motifs: | PB0135.1 aarawCbATTArsr M1072_1.02 yTAATkrsyt PB0031.1 tkgagbTAATTAry PH0050.1 tygmrbTAATTAry |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.