Transcription Factor
| Accessions: | T049631_1.02 (CISBP 1.02), ZFX_MOUSE (HOCOMOCO 10), P17012 (JASPAR 2024) |
| Names: | T049631_1.02;, Zfx, ZFX_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 799 |
| Pfam Domains: | 70-404 Zfx / Zfy transcription activation region 419-441 Zinc finger, C2H2 type 419-441 C2H2-type zinc finger 434-459 Zinc-finger double domain 450-472 C2H2-type zinc-finger domain 483-504 C2H2-type zinc finger 483-504 Zinc finger, C2H2 type 513-536 C2H2-type zinc-finger domain 528-553 Zinc-finger double domain 542-564 C2H2-type zinc finger 542-564 Zinc finger, C2H2 type 557-578 Zinc-finger double domain 570-593 Zinc finger, C2H2 type 570-593 C2H2-type zinc finger 570-593 C2H2-type zinc-finger domain 584-609 Zinc-finger double domain 599-621 C2H2-type zinc finger 627-650 C2H2-type zinc finger 641-666 Zinc-finger double domain 656-678 Zinc finger, C2H2 type 656-678 C2H2-type zinc finger 671-691 Zinc-finger double domain 684-708 C2H2-type zinc-finger domain 684-707 C2H2-type zinc finger 699-723 Zinc-finger double domain 713-735 Zinc finger, C2H2 type 713-735 C2H2-type zinc finger 728-751 Zinc-finger double domain 741-764 C2H2-type zinc finger 741-764 Zinc finger, C2H2 type 756-780 Zinc-finger double domain 770-793 C2H2-type zinc finger 770-792 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MDEDGLELQQQAPNSFFDATGAGATHMDGNQIVVEVQETVYVSDVVDSDITVHNYVPDDP 60 61 DSVVIQDVIEDVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLA 120 121 SDITSASISMPEHVLTSESIHVSDVGHVEHVVHDSVVEAEIVTDPLAADVVSEEVLVADC 180 181 ASEAVIDANGIPVNQQDEEKNNCEDYLMISLDDAGKIEHDGSSGLTMDNETEIDPCKVDG 240 241 TCPEVIKVYIFKADPGEDDLGGTVDIVESEPENEHGVELLDPNNSIRVPREKMVYMAVND 300 301 SQQEEEELNVAEIADEVYMEVIVGEEDAAAAAAAAVHEQQVEDNEMKTFMPIAWAAAYGN 360 361 NSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYP 420 421 CMICGKKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEK 480 481 AIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNF 540 541 PHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSADSSNLKTHVKTKHSKEMPFK 600 601 CDICLLTFSDTKEVQQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDM 660 661 CDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRK 720 721 GFRQQSELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFR 780 781 RPSEKNQHIMRHHKEVGLP |
| Interface Residues: | 461, 463, 465, 467, 468, 492, 495, 496, 499, 523, 524, 525, 526, 527, 528, 529, 530, 531, 534, 552, 553, 554, 555, 556, 558, 559, 560, 561, 562, 563, 565, 580, 581, 582, 583, 584, 585, 586, 587, 588, 599, 609, 610, 611, 612, 613, 615, 616, 620, 638, 639, 640, 641, 643, 644, 647, 667, 668, 669, 670, 672, 673, 679, 693, 695, 697, 698, 699, 701, 702, 706, 723, 724, 725, 726, 727, 728, 730, 751, 752, 753, 754, 755, 757, 758, 759, 760, 762, 781, 783, 784 |
| 3D-footprint Homologues: | 7w1m_H, 2i13_A, 6jnm_A, 7n5w_A, 2kmk_A, 7eyi_G, 7y3l_A, 3uk3_C, 8cuc_F, 1g2f_F, 8ssu_A, 1tf6_A, 4x9j_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 1mey_C, 5kl3_A, 1f2i_J, 5k5i_A, 8ssq_A, 8h9h_G, 4m9v_C, 2lt7_A, 7y3m_I, 6wmi_A, 6a57_A, 2jpa_A, 6ml4_A, 1llm_D, 2wbs_A, 5yj3_D, 5und_A, 2gli_A, 5v3j_F, 5yel_A, 5k5l_F, 8gn3_A, 6e94_A, 7ysf_A, 7txc_E, 1tf3_A, 2drp_D |
| Binding Motifs: | M0444_1.02 ykyGGCCyw ZFX_MOUSE.H10MO.C|M01420 svsssscscAGGCCbsGsc MA0146.1 sssgsCbvGGCCTs MA0146.2 sssgsCbvGGCCTs MA0146.3 gsCbvGGCCT |
| Binding Sites: | MA0146.1.1 MA0146.1.10 MA0146.1.11 MA0146.1.12 MA0146.1.13 MA0146.1.14 MA0146.1.15 MA0146.1.16 MA0146.1.17 MA0146.1.18 MA0146.1.19 MA0146.1.2 MA0146.1.20 MA0146.1.3 MA0146.1.4 MA0146.1.5 MA0146.1.6 MA0146.1.7 MA0146.1.8 MA0146.1.9 |
| Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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