Transcription Factor
| Accessions: | Q8IXZ3 (JASPAR 2024) |
| Names: | SP8_HUMAN, Specificity protein 8, Transcription factor Sp8 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8IXZ3 |
| Length: | 490 |
| Pfam Domains: | 356-380 C2H2-type zinc finger 356-380 Zinc finger, C2H2 type 372-399 Zinc-finger double domain 386-410 C2H2-type zinc finger 386-410 Zinc finger, C2H2 type 403-425 Zinc-finger double domain 416-438 C2H2-type zinc finger 416-438 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGAS 60 61 RNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSP 120 121 FANDYSVFQAPGVSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVG 180 181 MAHPYESWFKPSHPGLGAAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGL 240 241 QTSLHSPLGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLA 300 301 GAGGSMLSAGPSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHI 360 361 PGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPV 420 421 CNKRFMRSDHLSKHVKTHSGGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQP 480 481 PEPGHRNGLE |
| Interface Residues: | 345, 346, 348, 351, 352, 353, 354, 368, 369, 370, 371, 372, 374, 375, 377, 378, 381, 397, 398, 399, 400, 401, 402, 404, 405, 406, 409, 426, 427, 428, 429, 430, 431, 432, 433, 434, 454, 457, 458 |
| 3D-footprint Homologues: | 5kkq_D, 8ssq_A, 7w1m_H, 8ssu_A, 7ysf_A, 1ubd_C, 7n5w_A, 1tf3_A, 6jnm_A, 8cuc_F, 2i13_A, 6blw_A, 6u9q_A, 5yel_A, 5ei9_F, 1mey_C, 5kl3_A, 5k5i_A, 2kmk_A, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 1tf6_A, 6ml4_A, 4x9j_A, 8h9h_G, 7eyi_G, 5v3j_F, 7y3m_I, 6e94_A, 6wmi_A, 2lt7_A, 6a57_A, 2jpa_A, 3uk3_C, 7y3l_A, 1llm_D, 2wbs_A, 7txc_E, 2drp_D, 1f2i_J, 4m9v_C, 8gn3_A, 5yj3_D |
| Binding Motifs: | MA0747.1 rmCACgCCCmCy MA0747.2 mCACgCCCmCy |
| Publications: | Yokoyama KD, Pollock DD. SP transcription factor paralogs and DNA-binding sites coevolve and adaptively converge in mammals and birds. Genome Biol Evol : (2012;4(11):1102-17.). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.