Transcription Factor
| Accessions: | CENPB_full (HumanTF 1.0) |
| Names: | CENP-B, CENPB, CENPB_HUMAN, Centromere protein B, Major centromere autoantigen B |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | P07199 |
| Notes: | Ensembl ID: ENSG00000125817; Full protein sequence; TF family: CENPB; Clone source: hORFeome |
| Length: | 600 |
| Pfam Domains: | 3-55 CENP-B N-terminal DNA-binding domain 74-135 Tc5 transposase DNA-binding domain 186-384 DDE superfamily endonuclease 499-599 Centromere protein B dimerisation domain |
| Sequence: (in bold interface residues) | 1 MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYG 60 61 VASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASN 120 121 GWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAVPSEGSGGSTTGWRAREEQPP 180 181 SVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRPRQATQRLSVLLCANADGSEKLP 240 241 PLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLA 300 301 AQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLG 360 361 LTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEEG 420 421 EGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGV 480 481 VEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVP 540 541 VPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS* 600 |
| Interface Residues: | 40, 44, 47, 48, 263, 272, 273, 274, 275, 277 |
| 3D-footprint Homologues: | 5hso_A, 1jgg_B, 5ht2_B, 5tvp_M |
| Binding Motifs: | CENPB_full CCCGywTmswrCGAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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