Transcription Factor

						

			
Accessions: pan (DrosophilaTF 1.1), P91943 (JASPAR 2024)

			
Names: dTCF, PANG1_DROME, Protein pangolin, isoforms A/H/I, Protein pangolin, isoforms A/H/I/S
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, JASPAR 2024 2
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 751
Pfam Domains:     1-159 N-terminal CTNNB1 binding
  273-340 HMG (high mobility group) box
  274-331 Domain of unknown function (DUF1898)
Sequence: 
(in bold interface residues)		   1 MPHTHSRHGSSGDDLCSTDEVKIFKDEGDREDEKISSENLLVEEKSSLIDLTESEEKGHK   60
  61 ISRPDHSPVFNKLDTHAPSFNMGYLVSPYSYANGSPSGLPVTMANKIGLPPFFCHNADPL  120
 121 STPPPAHCGIPPYQLDPKMGLTRPALYPFAGGQYPYPMLSSDMSQVASWHTPSVYSASSF  180
 181 RTPYPSSLPINTTLASDFPFRFSPSLLPSVHATSHHVINAHSAIVGVSSKQECGVQDPTT  240
 241 NNRYPRNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKES  300
 301 AAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRS  360
 361 TTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQL  420
 421 SDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPSTTMSLA  480
 481 SPLNMNANSATNVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSS  540
 541 TVSPVTCMTGPCLGSSQERAMMLGNRFSHLGMGLSPPVVSTSTSKSEPFFKPHPTVCNNP  600
 601 IFALPSIGNCSLNISSMPNTSRNPIGANPRDINNPLSINQLTKRREYKNVELIEASESKT  660
 661 IVAHAATSIIQHVAVNGYHANHSLLNSNLGHLHHQLNNRTENPNRSEQTMLSVSNHSVNS  720
 721 SECHKESDSQAIVSSNPPNAGSSDNGVISVS
Interface Residues: 275, 278, 280, 281, 284, 288, 299, 300, 301, 304, 342, 344, 346, 348, 350, 352, 355, 373, 390, 391, 392
3D-footprint Homologues: 3f27_D, 4s2q_D, 1o4x_B, 7m5w_A, 3tmm_A, 4y60_C, 2gzk_A, 6jrp_D, 2lef_A, 3u2b_C, 1j5n_A, 3tq6_B, 1hry_A, 7dta_A
Binding Motifs: MA0237.1 yTTTGAWm
pan CCTTTGATCTT
Binding Sites: MA0237.1.1
MA0237.1.10
MA0237.1.11
MA0237.1.12
MA0237.1.13
MA0237.1.14
MA0237.1.15
MA0237.1.16
MA0237.1.17
MA0237.1.18
MA0237.1.19
MA0237.1.2
MA0237.1.20
MA0237.1.3
MA0237.1.4
MA0237.1.5
MA0237.1.6
MA0237.1.7
MA0237.1.8
MA0237.1.9
			
Publications: van der Wetering M., Cavallo R., Dooijes D., van Beest M., van Es J., Loureiro J., Ypma A., Hursh D., Jones T., Bejsovec A., Peifer M., Mortin M., Clevers H. Armadillo coactivates transcription driven by the product of the drosophila segment polarity gene dTCF. Cell 88:789-799 (1997). [Pubmed]


Bergman C.M, Carlson J.W, Celniker S.E. Drosophila DNase I footprint database: a systematic genome annotation of transcription factor binding sites in the fruitfly, Drosophila melanogaster. Bioinformatics (Oxford, England) 21:1747-9 (2005). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.