Transcription Factor

Accessions: P41161 (JASPAR 2024)
Names: ETS translocation variant 5, Ets-related protein ERM, ETV5_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 510
Pfam Domains: 1-366 PEA3 subfamily ETS-domain transcription factor N terminal domain
368-449 Ets-domain
Sequence:
(in bold interface residues)
1 MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAE 60
61 AQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNY 120
121 CAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHS 180
181 LPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNR 240
241 PSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYC 300
301 VDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGP 360
361 PYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYD 420
421 KLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDT 480
481 LPLTHFEDSPAYLLDMDRCSSLPYAEGFAY
Interface Residues: 420, 421, 423, 424, 425, 427, 428, 442
3D-footprint Homologues: 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A
Binding Motifs: MA0765.1 acCGGAwgyr
MA1944.1 rsmGGAAGyAATTA
MA1948.1 rsCGGAwGTmATTA
MA0765.2 bcACTTCCGsy
MA0765.3 ACCGGAAGTr
MA0765.4 ACCGGAAGT
MA1944.2 mGGAAGyAATTA
MA1948.2 CGGAwGTmATTA
Binding Sites: MA0765.2.1
MA0765.2.10
MA0765.2.11
MA0765.2.12
MA0765.2.13
MA0765.2.14
MA0765.2.15
MA0765.2.16
MA0765.2.17
MA0765.2.18
MA0765.2.19
MA0765.2.2
MA0765.2.20 / MA0765.2.9
MA0765.2.3
MA0765.2.4
MA0765.2.5
MA0765.2.6
MA0765.2.7
MA0765.2.8
Publications: Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed]

Cooper C.D, Newman J.A, Aitkenhead H, Allerston C.K, Gileadi O. Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. The Journal of biological chemistry : (2015). [Pubmed]

Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]
Related annotations: PaperBLAST

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