Transcription Factor

						

			
Accessions: PO2F2_MOUSE (HOCOMOCO 10), Q00196 (JASPAR 2024)

			
Names: Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, PO2F2_MOUSE, POU domain, class 2, transcription factor 2
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q00196
Length: 463
Pfam Domains:   180-253 Pou domain - N-terminal to homeobox domain
  282-338 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS   60
  61 TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL  120
 121 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE  180
 181 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK  240
 241 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF  300
 301 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPTSYSPH  360
 361 LVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT  420
 421 PPPPATTNSTNPSPQGSHSAIGLSGLNPSAGPGLWWNPAPYQP
Interface Residues: 205, 221, 222, 223, 224, 226, 227, 233, 237, 281, 282, 283, 284, 285, 323, 324, 326, 327, 330, 331, 334, 335, 338
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 8g87_X, 1o4x_A, 2xsd_C, 1e3o_C, 1au7_A, 7xrc_C, 3a01_E, 3cmy_A, 2h1k_B, 1ig7_A, 5zjt_E, 4cyc_A, 1puf_A, 1fjl_B, 2lkx_A, 1nk2_P, 1jgg_B, 1zq3_P, 3lnq_A, 7q3o_C, 6es3_K, 2ld5_A, 1b72_A, 7psx_B, 3rkq_B, 2r5y_A, 2hdd_A, 5jlw_D, 1le8_A, 4xrs_G, 1du0_A, 5flv_I, 5hod_A, 6fqp_B, 4qtr_D
Binding Motifs: PO2F2_MOUSE.H10MO.B|M01294 tATGCAAAT
PH0144.1 ywkTATGCWAATkara
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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