Transcription Factor
Accessions: | ALX1_MOUSE (HOCOMOCO 10), Q8C8B0 (JASPAR 2024) |
Names: | ALX homeobox protein 1, ALX1_MOUSE, CART-1, Cartilage homeoprotein 1 |
Organisms: | Mus musculus |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 326 |
Pfam Domains: | 133-189 Homeobox domain 302-321 OAR domain |
Sequence: (in bold interface residues) | 1 MEFLSEKFALKSPPSKNSDFYMGTGGALEHVMETLDNESFYGKATAGKCVQAFGPLPRAE 60 61 HHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNNLRMSPVKGMPEKSELDELG 120 121 DKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWF 180 181 QNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCM 240 241 LPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPE 300 301 FERRSSSIAVLRMKAKEHTANISWAM |
Interface Residues: | 132, 133, 134, 135, 136, 174, 175, 177, 178, 181, 182, 185, 186, 189 |
3D-footprint Homologues: | 4j19_B, 6a8r_A, 3d1n_M, 1fjl_B, 5zfz_A, 2h1k_B, 1ig7_A, 1puf_A, 3cmy_A, 1zq3_P, 1nk2_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 7q3o_C, 6es3_K, 2ld5_A, 1puf_B, 2hos_A, 5jlw_D, 4cyc_A, 4xrs_G, 3l1p_A, 1b72_A, 3a01_E, 5flv_I, 5zjt_E, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1e3o_C, 1le8_A, 2xsd_C, 7xrc_C, 4xrm_B, 1du0_A, 4qtr_D |
Binding Motifs: | ALX1_MOUSE.H10MO.B|M01003 rTAATtrvATTA MA0854.1 / PH0010.1 cgmryTAATTArtymcy PH0011.1 crmrTTAATTAAttgrm MA0854.2 yTAATTAr |
Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.