Transcription Factor

						

			
Accessions: Sox11_DBD (HumanTF 1.0), UP00030A (UniPROBE 20160601)

			
Names: Sox11, SOX11_MOUSE, 1110038H03Rik, 6230403H02Rik, AI836553, end1, Sox-11, SRY-box containing gene 11, Transcription factor SOX-11
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q04889
Description: SRY-box containing gene 11
Notes: Ensembl ID: ENSMUSG00000063632; DNA-binding domain sequence; TF family: HMG; Clone source: Hughes lab.
Length: 101
Pfam Domains:     17-85 HMG (high mobility group) box
    18-75 Domain of unknown function (DUF1898)
Sequence: 
(in bold interface residues)		   1 ALDESDTDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKD   60
  61 SEKIPFIREAERLRLKHMADYPDYKYRPRKKPKTDSAAKPS
Interface Residues: 19, 22, 24, 25, 26, 28, 32, 43, 44, 45, 48, 86, 90
3D-footprint Homologues: 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 1hry_A, 3tq6_B, 1ckt_A
Binding Motifs: UP00030A_1 wkwarAACAAWGraywa
Sox11_DBD AACAATTkCAGTGTT
UP00030A_2 arAATTGTywkrrw
Binding Sites: AAACAAAG
AAACAATT
AACAAAGA
AACAATAA
AACAATAG
AACAATTG
AAGACAAT
AATTGTTC
ACAAAGAA
ACAAAGGA
ACAACAAT
ACAATTGT
AGAACAAT
AGACAATA
ATTGTTCA
CATTGTTC
CTTTGTTC
GAACAATA
GACAAAGA
ATTGTCTC
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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