Transcription Factor
| Accessions: | EGR2_MOUSE (HOCOMOCO 10), P08152 (JASPAR 2024) |
| Names: | E3 SUMO-protein ligase EGR2, Early growth response protein 2, EC 6.3.2.-, EGR-2, EGR2_MOUSE, Zinc finger protein Krox-20, E3 SUMO-protein transferase ERG2, EC 2.3.2.- |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P08152 |
| Length: | 470 |
| Pfam Domains: | 94-184 Domain of unknown function (DUF3446) 337-361 C2H2-type zinc finger 337-361 Zinc finger, C2H2 type 354-377 Zinc-finger double domain 367-389 C2H2-type zinc finger 367-389 Zinc finger, C2H2 type 381-405 Zinc-finger double domain 395-413 C2H2-type zinc finger 395-417 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAASSVTIFPNGELGGPFDQMNGVAGDGMI 60 61 NIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGI 120 121 LQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPELDHLYSPPPPPPPYSGCTGD 180 181 LYQDPSAFLSPPSTTSTSSLAYQPPPSYPSPKPAMDPGLIPMIPDYPGFFPSPCQRDPHG 240 241 AAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPGAGVTGPGASGGGEGPRLPGSGSA 300 301 AVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRI 360 361 HTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQ 420 421 KERKSSAPSAPPSAQSSASGPGGSQAGGSLCGNSAIGGPLASCTSRTRTP |
| Interface Residues: | 238, 263, 267, 303, 304, 306, 316, 319, 323, 326, 328, 329, 349, 350, 351, 352, 353, 355, 356, 375, 377, 378, 379, 380, 381, 383, 384, 385, 402, 405, 406, 407, 408, 409, 410, 411, 412, 413, 416, 439, 440, 441, 451, 454 |
| 3D-footprint Homologues: | 7w1m_H, 5kkq_D, 8ssu_A, 8ssq_A, 1tf6_A, 5ei9_F, 7n5w_A, 6jnm_A, 2kmk_A, 1tf3_A, 6u9q_A, 4x9j_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 2jpa_A, 1mey_C, 5und_A, 7ysf_A, 1f2i_J, 5k5i_A, 6ml4_A, 2gli_A, 1g2f_F, 6blw_A, 8h9h_G, 5v3j_F, 7eyi_G, 2lt7_A, 6e94_A, 6wmi_A, 6a57_A, 2drp_D, 7y3l_A, 3uk3_C, 8cuc_F, 5yel_A, 1llm_D, 7txc_E, 4m9v_C, 7y3m_I, 8gn3_A, 7ej7_B, 5yj3_D |
| Binding Motifs: | MA0472.1 cmcmCrCCCACrCac EGR2_MOUSE.H10MO.C|M01062 gGcGkGGGCGg |
| Binding Sites: | MA0472.1.1 MA0472.1.10 MA0472.1.11 MA0472.1.12 MA0472.1.13 MA0472.1.14 MA0472.1.15 MA0472.1.16 MA0472.1.17 MA0472.1.18 MA0472.1.19 MA0472.1.2 MA0472.1.20 MA0472.1.3 MA0472.1.4 MA0472.1.5 MA0472.1.6 MA0472.1.7 MA0472.1.8 MA0472.1.9 |
| Publications: | Swirnoff A. H., Milbrandt J. DNA-binding specificity of NGFI-A and related zinc finger transcription factors. Mol. Cell. Biol. 15:2275-2287 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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