Transcription Factor

						

			
Accessions: Q9Y2V3 (JASPAR 2024)

			
Names: Retina and anterior neural fold homeobox protein, Retinal homeobox protein Rx, RX_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9Y2V3
Length: 346
Pfam Domains:   137-193 Homeobox domain
  318-338 OAR domain
Sequence: 
(in bold interface residues)		   1 MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGA   60
  61 KERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPA  120
 121 TGEAKLSEEEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRV  180
 181 QVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALP  240
 241 LESWLGPPLPGGGATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPPP  300
 301 PSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQAIGKPWQAL
Interface Residues: 88, 89, 90, 91, 93, 94, 101, 105, 131, 136, 137, 138, 139, 140, 178, 179, 181, 182, 185, 186, 189, 190, 193, 194
3D-footprint Homologues: 3l1p_A, 3a01_E, 3d1n_M, 5zfz_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1puf_B, 1fjl_B, 1nk2_P, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 1ig7_A, 5flv_I, 5zjt_E, 4j19_B, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: MA0718.1 ryyAATTAry
MA0718.2 yAATTA
			
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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