Transcription Factor

Accessions: T082897_1.02 (CISBP 1.02), Q7RY86 (JASPAR 2024)
Names: NCU00019, T082897_1.02;, Q7RY86_NEUCR
Organisms: Neurospora crassa, Neurospora crassa OR74A
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Forkhead
Length: 688
Pfam Domains: 123-206 FHA domain
330-420 Fork head domain
Sequence:
(in bold interface residues)
1 MSPSPPKHTASFNTADQHNLSDPVTGDSSPSRPSKRRKKDDDAPTDLADEADSSLVADQS 60
61 ALDMNDDDQVVARVIQYLEMPKNVQASKDHSNSIHESSQGVQAFAKIAANDWTYYIMSLN 120
121 VNIGRSSEPIQATTGQSQEEDPSKVVHIDLGPNKQVSRQHALIYFKSTEEQWWLRVKGRN 180
181 ALKVDGVPWKVGDEGPLRSGEVIEIGGMEMMFVLPADISALQIKRDYLERAGIVPPDSQV 240
241 SPRQARHPLPSAGESHAFQAVSPTSKAAPRNQGPQKALAPAPPDYRRGVTPPLNLPRPPM 300
301 HRPVHEGLAGPLVMTNNEVDLSLDENQHIKPQFSYAQMITQAIVNTEDQKLNLSGIYQFI 360
361 MNRYSYYRHQPAGGWQNSIRHNLSLNKSFEKVARSTDEPGKGMKWQIVADAREDMIRNAY 420
421 RGGRGGHRGTSNPASPSGLNYITQGPKDMAAKEPASSRKRKISPSDSPQPQPHPTLRDSQ 480
481 STPVRAAQRKPLPDKAEDGTEASPLSTIRKPATMSTLGIVEDTPASPTLGPSYLQEDGAS 540
541 LVTPAPNRVNPRLVPPSTAQRPSQHMPTSSPAPFWRYADISSTPLKPAQYDASPSKTHGN 600
601 LPSQSSSPPPPARSKSPAGSASPSRTTSRGATVGVEESPSPAEEEEDRAFDLTKGFQSIG 660
661 SYHAPVSRGKEVQPAGNGDVPSMAPLSS
Interface Residues: 327, 371, 374, 376, 377, 378, 380, 381, 382, 384, 385, 394, 401
3D-footprint Homologues: 7yzb_A, 3l2c_A, 7vox_H, 2hdc_A, 7tdx_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 3qrf_G
Binding Motifs: M0743_1.02 atwGTAAAyAaa
MA0929.1 atwGTAAAyAaa
MA0929.2 GTAAAyA
Publications: Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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