Transcription Factor

						

			
Accessions: FOS (SMILE-seq 1.0)

			
Names: Cellular oncogene fos, FOS, FOS_HUMAN, G0/G1 switch regulatory protein 7, Proto-oncogene c-Fos
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P01100
Notes: TF family: bZIP
Length: 379
Pfam Domains:   135-194 bZIP transcription factor
  137-189 Basic region leucine zipper
Sequence: 
(in bold interface residues)		   1 MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF   60
  61 IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA  120
 121 QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ  180
 181 TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT  240
 241 LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA  300
 301 ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK  360
 361 GSSSNEPSSDSLSSPTLLA
Interface Residues: 143, 144, 147, 148, 150, 151, 154, 155, 158
3D-footprint Homologues: 4eot_A, 7x5e_E, 7x5e_F, 2wt7_A, 6mg1_B, 1nwq_C, 1skn_P, 5vpe_C, 5vpe_D
Binding Motifs: JUNB_FOS_1 krTGAsTCAymv
JUND_FOS_1 kkrTGAGTCAymv
JUN_FOS_1 rTGAGTCAym
JUN_FOS_2 drTgACGTCAtmmkty
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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