Transcription Factor
Accessions: | ZNF136 (humanC2H2ZF-ChIP Feb2015), P52737 (JASPAR 2024) |
Names: | ENSG00000196646, P52737, ZNF136, ZN136_HUMAN |
Organisms: | Homo sapiens |
Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Notes: | TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
Length: | 540 |
Pfam Domains: | 4-44 KRAB box 155-177 Zinc-finger double domain 168-187 C2H2-type zinc finger 168-190 C2H2-type zinc finger 184-206 Zinc-finger double domain 195-218 C2H2-type zinc finger 196-218 C2H2-type zinc finger 196-218 Zinc finger, C2H2 type 211-235 Zinc-finger double domain 223-246 C2H2-type zinc finger 224-246 C2H2-type zinc finger 239-262 Zinc-finger double domain 251-270 C2H2-type zinc finger 252-274 Zinc finger, C2H2 type 252-274 C2H2-type zinc finger 267-291 Zinc-finger double domain 280-302 C2H2-type zinc finger 280-298 C2H2-type zinc finger 295-319 Zinc-finger double domain 307-324 C2H2-type zinc finger 308-330 Zinc finger, C2H2 type 308-330 C2H2-type zinc finger 322-346 Zinc-finger double domain 336-358 Zinc finger, C2H2 type 336-358 C2H2-type zinc finger 336-351 C2H2-type zinc finger 352-375 Zinc-finger double domain 363-386 C2H2-type zinc finger 364-386 C2H2-type zinc finger 379-402 Zinc-finger double domain 391-408 C2H2-type zinc finger 392-414 Zinc finger, C2H2 type 408-431 Zinc-finger double domain 420-432 C2H2-type zinc finger 420-442 Zinc finger, C2H2 type 420-442 C2H2-type zinc finger 436-459 Zinc-finger double domain 447-466 C2H2-type zinc finger 448-470 Zinc finger, C2H2 type 448-468 C2H2-type zinc finger 463-486 Zinc-finger double domain 475-498 C2H2-type zinc finger 476-498 Zinc finger, C2H2 type 476-498 C2H2-type zinc finger 491-515 Zinc-finger double domain 504-526 C2H2-type zinc finger 504-526 C2H2-type zinc finger |
Sequence: (in bold interface residues) | 1 MDSVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKKWKDQNIKDHYKHRG 60 61 RNLRSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKLCESIVYGEVSMGQSSLNRH 120 121 IKDHSGHEPKEYQEYGEKPDTRNQCWKPFSSHHSFRTHEIIHTGEKLYDCKECGKTFFSL 180 181 KRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVR 240 241 RHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPFKCKQCGKAFSCSPTLRIHER 300 301 THTGEKPYECKQCGKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTG 360 361 EKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFHSLSPFRIHERTHTGEKPY 420 421 VCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEMIHTGEKPFECKR 480 481 CGKAFRSSSSFRLHERTHTGQKPYHCKECGKAYSCRASFQRHMLTHAEDGPPYKCMWESL 540 |
Interface Residues: | 210, 224, 235, 236, 237, 238, 241, 262, 263, 264, 265, 266, 268, 269, 271, 272, 275, 290, 291, 292, 293, 294, 296, 297, 301, 318, 319, 320, 321, 322, 323, 325, 346, 347, 348, 349, 350, 352, 353, 354, 375, 376, 377, 378, 379, 380, 381, 382, 402, 403, 404, 405, 406, 409, 412, 430, 431, 433, 434, 436, 437, 443, 457, 459, 460, 461, 462, 463, 465, 469, 486, 487, 488, 489, 490, 493, 514, 515, 516, 517, 518, 520, 521 |
3D-footprint Homologues: | 5yel_A, 2kmk_A, 5yj3_D, 7ysf_A, 7w1m_H, 7y3l_A, 7n5w_A, 1g2f_F, 4x9j_A, 1f2i_J, 8h9h_G, 7y3m_I, 2jpa_A, 6jnm_A, 8ssu_A, 2gli_A, 5kkq_D, 1llm_D, 5kl3_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7eyi_G, 6e94_A, 6a57_A, 8cuc_F, 6ml4_A, 5v3j_F, 7txc_E, 5und_A, 3uk3_C, 1tf6_A, 6u9q_A, 2i13_A, 5k5i_A, 4m9v_C, 1ubd_C, 1tf3_A, 6blw_A, 2lt7_A, 8gn3_A, 2wbs_A, 2drp_D |
Binding Motifs: | ZNF136_ChIP AAArcTrTCCTTCAr MA1588.1 rwATTCTtGGTTGrc |
Binding Sites: | MA1588.1.1 MA1588.1.10 / MA1588.1.8 MA1588.1.11 / MA1588.1.9 MA1588.1.10 / MA1588.1.12 MA1588.1.11 / MA1588.1.13 MA1588.1.12 / MA1588.1.14 MA1588.1.13 / MA1588.1.15 MA1588.1.14 / MA1588.1.16 MA1588.1.17 MA1588.1.18 MA1588.1.19 MA1588.1.2 MA1588.1.15 / MA1588.1.20 MA1588.1.3 MA1588.1.4 MA1588.1.4 / MA1588.1.5 MA1588.1.6 MA1588.1.5 / MA1588.1.7 MA1588.1.6 / MA1588.1.8 MA1588.1.7 / MA1588.1.9 MA1588.1.16 MA1588.1.17 MA1588.1.18 MA1588.1.19 MA1588.1.20 |
Publications: | Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.