Transcription Factor

Accessions: ZNF136 (humanC2H2ZF-ChIP Feb2015), P52737 (JASPAR 2024)
Names: ENSG00000196646, P52737, ZNF136, ZN136_HUMAN
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC
Length: 540
Pfam Domains: 4-44 KRAB box
155-177 Zinc-finger double domain
168-187 C2H2-type zinc finger
168-190 C2H2-type zinc finger
184-206 Zinc-finger double domain
195-218 C2H2-type zinc finger
196-218 C2H2-type zinc finger
196-218 Zinc finger, C2H2 type
211-235 Zinc-finger double domain
223-246 C2H2-type zinc finger
224-246 C2H2-type zinc finger
239-262 Zinc-finger double domain
251-270 C2H2-type zinc finger
252-274 Zinc finger, C2H2 type
252-274 C2H2-type zinc finger
267-291 Zinc-finger double domain
280-302 C2H2-type zinc finger
280-298 C2H2-type zinc finger
295-319 Zinc-finger double domain
307-324 C2H2-type zinc finger
308-330 Zinc finger, C2H2 type
308-330 C2H2-type zinc finger
322-346 Zinc-finger double domain
336-358 Zinc finger, C2H2 type
336-358 C2H2-type zinc finger
336-351 C2H2-type zinc finger
352-375 Zinc-finger double domain
363-386 C2H2-type zinc finger
364-386 C2H2-type zinc finger
379-402 Zinc-finger double domain
391-408 C2H2-type zinc finger
392-414 Zinc finger, C2H2 type
408-431 Zinc-finger double domain
420-432 C2H2-type zinc finger
420-442 Zinc finger, C2H2 type
420-442 C2H2-type zinc finger
436-459 Zinc-finger double domain
447-466 C2H2-type zinc finger
448-470 Zinc finger, C2H2 type
448-468 C2H2-type zinc finger
463-486 Zinc-finger double domain
475-498 C2H2-type zinc finger
476-498 Zinc finger, C2H2 type
476-498 C2H2-type zinc finger
491-515 Zinc-finger double domain
504-526 C2H2-type zinc finger
504-526 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MDSVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKKWKDQNIKDHYKHRG 60
61 RNLRSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKLCESIVYGEVSMGQSSLNRH 120
121 IKDHSGHEPKEYQEYGEKPDTRNQCWKPFSSHHSFRTHEIIHTGEKLYDCKECGKTFFSL 180
181 KRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVR 240
241 RHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPFKCKQCGKAFSCSPTLRIHER 300
301 THTGEKPYECKQCGKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTG 360
361 EKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFHSLSPFRIHERTHTGEKPY 420
421 VCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEMIHTGEKPFECKR 480
481 CGKAFRSSSSFRLHERTHTGQKPYHCKECGKAYSCRASFQRHMLTHAEDGPPYKCMWESL 540
Interface Residues: 210, 224, 235, 236, 237, 238, 241, 262, 263, 264, 265, 266, 268, 269, 271, 272, 275, 290, 291, 292, 293, 294, 296, 297, 301, 318, 319, 320, 321, 322, 323, 325, 346, 347, 348, 349, 350, 352, 353, 354, 375, 376, 377, 378, 379, 380, 381, 382, 402, 403, 404, 405, 406, 409, 412, 430, 431, 433, 434, 436, 437, 443, 457, 459, 460, 461, 462, 463, 465, 469, 486, 487, 488, 489, 490, 493, 514, 515, 516, 517, 518, 520, 521
3D-footprint Homologues: 5yel_A, 2kmk_A, 5yj3_D, 7ysf_A, 7w1m_H, 7y3l_A, 7n5w_A, 1g2f_F, 4x9j_A, 1f2i_J, 8h9h_G, 7y3m_I, 2jpa_A, 6jnm_A, 8ssu_A, 2gli_A, 5kkq_D, 1llm_D, 5kl3_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7eyi_G, 6e94_A, 6a57_A, 8cuc_F, 6ml4_A, 5v3j_F, 7txc_E, 5und_A, 3uk3_C, 1tf6_A, 6u9q_A, 2i13_A, 5k5i_A, 4m9v_C, 1ubd_C, 1tf3_A, 6blw_A, 2lt7_A, 8gn3_A, 2wbs_A, 2drp_D
Binding Motifs: ZNF136_ChIP AAArcTrTCCTTCAr
MA1588.1 rwATTCTtGGTTGrc
Binding Sites: MA1588.1.1
MA1588.1.10 / MA1588.1.8
MA1588.1.11 / MA1588.1.9
MA1588.1.10 / MA1588.1.12
MA1588.1.11 / MA1588.1.13
MA1588.1.12 / MA1588.1.14
MA1588.1.13 / MA1588.1.15
MA1588.1.14 / MA1588.1.16
MA1588.1.17
MA1588.1.18
MA1588.1.19
MA1588.1.2
MA1588.1.15 / MA1588.1.20
MA1588.1.3
MA1588.1.4
MA1588.1.4 / MA1588.1.5
MA1588.1.6
MA1588.1.5 / MA1588.1.7
MA1588.1.6 / MA1588.1.8
MA1588.1.7 / MA1588.1.9
MA1588.1.16
MA1588.1.17
MA1588.1.18
MA1588.1.19
MA1588.1.20
Publications: Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.