Transcription Factor
| Accessions: | CEBPA_HUMAN (HOCOMOCO 10), P49715 (JASPAR 2024) |
| Names: | C/EBP alpha, CCAAT/enhancer-binding protein alpha, CEBPA_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P49715 |
| Length: | 358 |
| Pfam Domains: | 282-334 Basic region leucine zipper 287-338 bZIP transcription factor |
| Sequence: (in bold interface residues) | 1 MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHET 60 61 SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVM 120 121 PGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFP 180 181 YQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPA 240 241 LGAAGLPGPGSALKGLGAAHPDLRASGGSGAGKAKKSVDKNSNEYRVRRERNNIAVRKSR 300 301 DKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA |
| Interface Residues: | 288, 289, 292, 293, 295, 296, 299, 300 |
| 3D-footprint Homologues: | 2wt7_A, 6mg1_B, 1nwq_C, 5vpe_D, 2dgc_A, 5t01_B, 2c9l_Z |
| Binding Motifs: | MA0102.3 aTTGCAyAAym CEBPA_HUMAN.H10MO.A|M01048 wrTTgTGCAAymw MA0102.4 wkATTGCACAAtww MA0102.5 ATTGCACAAt |
| Binding Sites: | MA0102.5.13 MA0102.5.1 MA0102.3.1 MA0102.3.10 MA0102.3.11 MA0102.3.12 MA0102.3.13 MA0102.3.14 MA0102.3.15 MA0102.3.16 MA0102.3.17 MA0102.3.18 MA0102.3.19 MA0102.3.2 MA0102.3.20 MA0102.3.3 MA0102.3.4 MA0102.3.5 MA0102.3.6 MA0102.3.7 MA0102.3.8 MA0102.3.9 MA0102.4.11 / MA0102.4.6 MA0102.4.12 / MA0102.4.7 MA0102.4.1 MA0102.4.10 / MA0102.4.5 MA0102.4.13 MA0102.4.14 / MA0102.4.8 MA0102.4.15 MA0102.4.16 MA0102.4.17 MA0102.4.10 / MA0102.4.18 MA0102.4.19 MA0102.4.2 MA0102.4.11 / MA0102.4.20 MA0102.4.3 MA0102.4.4 MA0102.4.3 / MA0102.4.5 MA0102.4.6 MA0102.4.4 / MA0102.4.7 MA0102.4.8 MA0102.4.9 MA0102.4.12 MA0102.4.13 MA0102.4.14 MA0102.4.15 MA0102.4.16 MA0102.4.17 MA0102.4.18 MA0102.4.19 MA0102.4.2 MA0102.4.20 MA0102.4.9 MA0102.5.10 MA0102.5.11 MA0102.5.12 MA0102.5.14 MA0102.5.15 MA0102.5.16 MA0102.5.17 MA0102.5.18 MA0102.5.19 MA0102.5.2 MA0102.5.20 / MA0102.5.4 MA0102.5.3 MA0102.5.5 MA0102.5.6 / MA0102.5.7 MA0102.5.8 MA0102.5.9 |
| Publications: | Grange T., Roux J., Rigaud G., Pictet R. Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res. 19:131-139 (1991). [Pubmed] Osada S, Yamamoto H, Nishihara T, Imagawa M. DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J Biol Chem 271:3891-6 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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