Transcription Factor
| Accessions: | EGR1_full (HumanTF 1.0), EGR1_HUMAN (HOCOMOCO 10), P18146 (JASPAR 2024) |
| Names: | EGR1, TOE1_HUMAN, AT225, Early growth response protein 1, EGR-1, EGR1_HUMAN, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | Ensembl ID: ENSG00000120738; Full protein sequence; TF family: znfC2H2; Clone source: hORFeome |
| Length: | 543 |
| Pfam Domains: | 135-219 Domain of unknown function (DUF3446) 338-362 Zinc finger, C2H2 type 338-362 C2H2-type zinc finger 355-378 Zinc-finger double domain 368-390 Zinc finger, C2H2 type 368-390 C2H2-type zinc finger 382-406 Zinc-finger double domain 396-418 Zinc finger, C2H2 type 396-414 C2H2-type zinc finger 428-467 Domain of unknown function (DUF3432) 454-530 Domain of unknown function (DUF3432) |
| Sequence: (in bold interface residues) | 1 MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGS 60 61 NSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETS 120 121 YPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAAS 180 181 SASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAY 240 241 PAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSG 300 301 SQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIR 360 361 IHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR 420 421 QKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSS 480 481 TYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTI 540 541 EIC |
| Interface Residues: | 320, 324, 327, 350, 351, 352, 353, 354, 356, 357, 376, 378, 379, 380, 381, 382, 383, 384, 385, 386, 406, 407, 408, 409, 410, 411, 412, 413, 414, 417 |
| 3D-footprint Homologues: | 5kkq_D, 8ssq_A, 7w1m_H, 8ssu_A, 7ysf_A, 5ei9_F, 7n5w_A, 6jnm_A, 2kmk_A, 1tf3_A, 2gli_A, 1g2f_F, 6blw_A, 1tf6_A, 6u9q_A, 5yel_A, 4x9j_A, 2i13_A, 5kl3_A, 1ubd_C, 6wmi_A, 2jpa_A, 1mey_C, 5und_A, 1f2i_J, 5k5i_A, 6ml4_A, 8h9h_G, 7eyi_G, 5v3j_F, 2lt7_A, 6e94_A, 6a57_A, 2drp_D, 3uk3_C, 8cuc_F, 7y3l_A, 1llm_D, 7txc_E, 2wbs_A, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D |
| Binding Motifs: | EGR1_full / MA0162.3 wACGCCCACGCAhw MA0162.2 sccCCgCCCMCkCc EGR1_HUMAN.H10MO.A|M01095 gggrkGyGkGGGhGGgrg MA0162.4 ccmCGCCCACgCms MA0162.5 mCGCCCACgC |
| Binding Sites: | MA0162.2.1 MA0162.2.10 MA0162.2.11 MA0162.2.12 MA0162.2.13 MA0162.2.14 MA0162.2.15 MA0162.2.16 MA0162.2.17 MA0162.2.18 MA0162.2.19 MA0162.2.2 MA0162.2.20 MA0162.2.3 MA0162.2.4 MA0162.2.5 MA0162.2.6 MA0162.2.7 MA0162.2.8 MA0162.2.9 MA0162.4.1 MA0162.4.10 / MA0162.4.6 MA0162.4.11 MA0162.4.12 / MA0162.4.7 MA0162.4.13 / MA0162.4.8 MA0162.4.14 / MA0162.4.9 MA0162.4.15 MA0162.4.10 / MA0162.4.16 MA0162.4.17 MA0162.4.12 / MA0162.4.18 MA0162.4.13 / MA0162.4.19 MA0162.4.2 MA0162.4.20 MA0162.4.2 / MA0162.4.3 MA0162.4.4 MA0162.4.5 MA0162.4.5 / MA0162.4.6 MA0162.4.7 MA0162.4.8 MA0162.4.9 MA0162.4.11 MA0162.4.14 MA0162.4.15 MA0162.4.16 MA0162.4.17 MA0162.4.18 MA0162.4.19 MA0162.4.20 MA0162.4.3 MA0162.5.1 MA0162.5.10 / MA0162.5.11 / MA0162.5.12 MA0162.5.13 / MA0162.5.5 / MA0162.5.6 / MA0162.5.7 MA0162.5.14 MA0162.5.15 MA0162.5.16 MA0162.5.17 MA0162.5.18 MA0162.5.19 MA0162.5.2 MA0162.5.20 MA0162.5.3 MA0162.5.4 MA0162.5.8 / MA0162.5.9 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Meng X, Brodsky M.H, Wolfe S.A. A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nature biotechnology 23:988-94 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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