Transcription Factor

						

			
Accessions: Alx1_DBD (HumanTF 1.0)

			
Names: ALX homeobox protein 1, Alx1, ALX1_MOUSE, CART-1, Cartilage homeoprotein 1
Organisms: Mus musculus
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q8C8B0
Notes: Ensembl ID: ENSMUSG00000036602; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab.
Length: 93
Pfam Domains:     17-73 Homeobox domain
    40-69 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 DELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARV   60
  61 QVWFQNRRAKWRKRERYGQIQQAKSHFAATYDI
Interface Residues: 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73
3D-footprint Homologues: 4j19_B, 5zfz_A, 2h1k_B, 1puf_A, 3cmy_A, 1fjl_B, 6a8r_A, 3d1n_M, 1ig7_A, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 3a01_E, 5flv_I, 5zjt_E, 2hdd_A, 7psx_B, 1au7_A, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hos_A, 1b72_A, 5jlw_D, 4cyc_A, 4xrs_G, 3l1p_A, 7xrc_C, 1e3o_C, 1le8_A, 2xsd_C, 1o4x_A, 1du0_A, 8g87_X, 4qtr_D, 4xrm_B
Binding Motifs: Alx1_DBD_1 yyyAATTArm
Alx1_DBD_2 yTAATywaATTAa
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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