Transcription Factor
| Accessions: | Q96KN3 (JASPAR 2024) |
| Names: | Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted homeobox 2, PKNX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q96KN3 |
| Length: | 472 |
| Pfam Domains: | 298-345 Homeobox domain 306-345 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP 60 61 IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH 120 121 KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL 180 181 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG 240 241 GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT 300 301 NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAP 360 361 KAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQA 420 421 MMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE |
| Interface Residues: | 289, 291, 292, 294, 333, 334, 336, 337, 340, 341, 342, 344, 345 |
| 3D-footprint Homologues: | 6fqp_B, 1puf_A, 1puf_B, 4j19_B, 1mnm_C, 2ld5_A, 1le8_A, 2lkx_A, 1le8_B, 6fqq_E, 2d5v_B, 1fjl_B, 4xrm_B, 7psx_B, 1k61_B, 4xrs_G |
| Binding Motifs: | MA0783.1 TGACAGsTGTCA |
| Publications: | Modica L, Iotti G, D'Avola A, Blasi F. Prep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway. PLoS One : (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.