Transcription Factor
| Accessions: | ERR3_HUMAN (HOCOMOCO 10), ERR3_MOUSE (HOCOMOCO 10), P62509 (JASPAR 2024) |
| Names: | ERR gamma-2, ERR3_HUMAN, Estrogen receptor-related protein 3, Estrogen-related receptor gamma, Nuclear receptor subfamily 3 group B member 3, ERR3_MOUSE |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P62508 |
| Length: | 458 |
| Pfam Domains: | 127-194 Zinc finger, C4 type (two domains) 253-449 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG 60 61 SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML 120 121 NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC 180 181 QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH 240 241 LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL 300 301 LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK 360 361 LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT 420 421 LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV |
| Interface Residues: | 16, 136, 137, 139, 140, 146, 147, 149, 150, 153, 154, 178, 200, 202, 204, 207, 209, 211, 231 |
| 3D-footprint Homologues: | 7sr6_F, 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 1dsz_A, 4umm_E, 3cbb_A, 7xv6_B, 4iqr_B, 2han_A, 1hcq_E, 8cef_H, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 2nll_B, 1lat_A, 2ff0_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B |
| Binding Motifs: | MA0643.1 tsAAGGTCAw ERR3_HUMAN.H10MO.B|M01117 / ERR3_MOUSE.H10MO.B|M01077 TCAAGGTCA MA0643.2 tsAAGGTCA |
| Publications: | Razzaque MA, Masuda N, Maeda Y, Endo Y, Tsukamoto T, Osumi T. Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition. Gene 340:275-82 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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