Transcription Factor

						

			
Accessions: P08235 (JASPAR 2024)

			
Names: MCR_HUMAN, Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P08235
Length: 984
Pfam Domains:   602-669 Zinc finger, C4 type (two domains)
  755-938 Ligand-binding domain of nuclear hormone receptor
Sequence: 
(in bold interface residues)		   1 METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST   60
  61 QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE  120
 121 QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAI  180
 181 VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN  240
 241 AENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP  300
 301 ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP  360
 361 SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD  420
 421 SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF  480
 481 DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR  540
 541 DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS  600
 601 KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL  660
 661 QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN  720
 721 TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV  780
 781 VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM  840
 841 HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI  900
 901 KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML  960
 961 VEIISDQLPKVESGNAKPLYFHRK
Interface Residues: 555, 611, 612, 614, 615, 621, 622, 624, 625, 628, 629, 653, 677, 678, 680, 682, 688, 691, 693
3D-footprint Homologues: 6waa_D, 2xkk_C, 6fbq_A, 7wnh_D, 6l6q_B, 1a6y_A, 3g9m_B, 1lo1_A, 4oln_B, 3cbb_A, 7xv6_B, 4iqr_B, 2han_B, 1kb2_B, 2a66_A, 8cef_H, 5krb_G, 2nll_B, 1lat_A, 2ff0_A, 1dsz_A, 8hbm_B, 2han_A, 1hcq_E, 4umm_E, 1r4i_A, 5emc_A, 5cbx_B, 3g6t_A, 7prw_B, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B
Binding Motifs: MA0727.1 krGwACAywrTGTwCyc
MA0727.2 rGwACAywrTGTwCy
			
Publications: Sandelin A, Wasserman W.W. Prediction of nuclear hormone receptor response elements. Molecular endocrinology (Baltimore, Md.) 19:595-606 (2005). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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