Transcription Factor
| Accessions: | T086746_1.02 (CISBP 1.02), Q9NP62 (JASPAR 2024) |
| Names: | GCM1, T086746_1.02;, Chorion-specific transcription factor GCMa, GCM motif protein 1, GCM1_HUMAN, Glial cells missing homolog 1, hGCMa |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9NP62 |
| Notes: | experiment type:PBM, family:GCM |
| Length: | 436 |
| Pfam Domains: | 29-169 GCM motif protein |
| Sequence: (in bold interface residues) | 1 MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHIYSSEDKNAQRHLSSWA 60 61 MRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICDKARQKQQRKRCPNCDGPL 120 121 KLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVNTAPSSVS 180 181 LSLKGSTETRSLPGETQSQGSLPLTWSFQEGVQLPGSYSGHLIANTPQQNSLNDCFSFSK 240 241 SYGLGGITDLTDQTSTVDPMKLYEKRKLSSSRTYSSGDLLPPSASGVYSDHGDLQAWSKN 300 301 AALGRNHLADNCYSNYPFPLTSWPCSFSPSQNSSEPFYQQLPLEPPAAKTGCPPLWPNPA 360 361 GNLYEEKVHVDFNSYVQSPAYHSPQEDPFLFTYASHPHQQYSLPSKSSKWDFEEEMTYLG 420 421 LDHCNNDMLLNLCPLR |
| Interface Residues: | 63, 64, 65, 67, 87, 100 |
| 3D-footprint Homologues: | 1odh_A, 4tnt_B |
| Binding Motifs: | MA0646.1 cATGCGGGTac M0810_1.02 srTrcgGGy UN0540.1 crCCCrCACGGAAGtr UN0541.1 rtGcGGGCGGAAGkg UN0542.1 aCCCGCArCCGGAAGy UN0543.1 rTGCGGGCGGAAGtg UN0544.1 aTrCGGGCGGAAGyr UN0545.1 rTGTTGATrcGGGy UN0546.1 aCCCsCAcCmATAAM UN0547.1 rTGcGGGTmATAAAm UN0548.1 rTGcGGGaAATCGATr UN0549.1 ATrCGGGyvyATTGTty MA0646.2 ATGCGGGTac UN0540.2 rCCCrCACGGAAGt UN0541.2 tGcGGGCGGAAG UN0544.2 aTrCGGGCGGAAGy UN0545.2 TGTTGATrcGGG UN0546.2 CCCsCAcCmATAAM UN0547.2 rTGcGGGTmATAAA UN0548.2 rTGcGGGaAATCGAT UN0549.2 ATrCGGGyvyATTGTt |
| Publications: | Akiyama Y., Hosoya T., Poole A. M., Hotta Y. The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc. Natl. Acad. Sci. USA 93:14912-14916 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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