Transcription Factor
| Accessions: | Q9CXV0 (JASPAR 2024) |
| Names: | Insulin gene enhancer protein ISL-2, ISL2_MOUSE, Islet-2 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9CXV0 |
| Length: | 359 |
| Pfam Domains: | 27-85 LIM domain 89-143 LIM domain 193-248 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ 60 61 YLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVC 120 121 SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPSL 180 181 RTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ 240 241 NKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP 300 301 WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET |
| Interface Residues: | 157, 158, 159, 162, 163, 169, 173, 190, 192, 193, 194, 195, 233, 234, 236, 237, 240, 241, 244, 245, 248 |
| 3D-footprint Homologues: | 1au7_A, 2r5y_A, 3d1n_M, 6m3d_C, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 5flv_I, 3l1p_A, 2hos_A, 1fjl_B, 7psx_B, 1b72_A, 5hod_A, 2ld5_A, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 3rkq_B, 4xrs_G, 2hdd_A, 5zfz_A, 5jlw_D, 2xsd_C, 1le8_A, 7q3o_C, 7xrc_C, 1e3o_C, 1k61_B, 8g87_X, 5zjt_E, 4qtr_D, 1o4x_A, 4xrm_B, 1le8_B, 1du0_A, 1puf_A, 6es3_K, 1mnm_C, 4cyc_A, 1puf_B |
| Binding Motifs: | PH0088.1 mhmaAyymMTTAakwy |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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