Transcription Factor
| Accessions: | EGR3 (HT-SELEX2 May2017), Q06889 (JASPAR 2024) |
| Names: | EGR3, ENSG00000179388, Early growth response protein 3, EGR-3, EGR3_HUMAN, Zinc finger protein pilot |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q06889 |
| Notes: | TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 387 |
| Pfam Domains: | 87-156 Domain of unknown function (DUF3446) 275-299 C2H2-type zinc finger 275-299 Zinc finger, C2H2 type 292-315 Zinc-finger double domain 305-327 C2H2-type zinc finger 305-327 Zinc finger, C2H2 type 319-343 Zinc-finger double domain 333-355 Zinc finger, C2H2 type 333-353 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVVHYNQMATENVMDIGLT 60 61 NEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGAL 120 121 STQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAK 180 181 PALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIH 240 241 PGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHT 300 301 GHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKE 360 361 KKAEKGGAPSASSAPPVSLAPVVTTCA |
| Interface Residues: | 257, 261, 264, 267, 270, 286, 287, 288, 289, 290, 291, 293, 294, 315, 316, 317, 318, 319, 321, 322, 323, 343, 344, 345, 346, 347, 348, 349, 350, 351, 354, 372 |
| 3D-footprint Homologues: | 5kkq_D, 8ssq_A, 7w1m_H, 8ssu_A, 6blw_A, 5ei9_F, 5v3j_F, 8gn3_A, 7n5w_A, 6jnm_A, 1tf3_A, 2gli_A, 1g2f_F, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 5kl3_A, 1ubd_C, 7ysf_A, 2jpa_A, 1mey_C, 5und_A, 1f2i_J, 2kmk_A, 6ml4_A, 8h9h_G, 7eyi_G, 2lt7_A, 6e94_A, 6wmi_A, 6a57_A, 3uk3_C, 8cuc_F, 7y3l_A, 5yel_A, 1llm_D, 7txc_E, 2wbs_A, 2drp_D, 5k5i_A, 4m9v_C, 7y3m_I, 5yj3_D |
| Binding Motifs: | MA0732.1 yhmCGCCCMCGCAyt EGR3_2 mmCGCCCACGCam EGR3_methyl_1 hmCGCCCACGCRh MA0732.2 mCGCCCMCGCA |
| Publications: | Swirnoff A. H., Milbrandt J. DNA-binding specificity of NGFI-A and related zinc finger transcription factors. Mol. Cell. Biol. 15:2275-2287 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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